Accumulation and turnover of extracellular matrix components are the hallmarks of tissue
injury. Fragmented hyaluronan stimulates the expression of inflammatory genes by a variety …

Bronchial asthma is a chronic inflammatory disease in which bronchial wall remodelling
plays a significant role. This phenomenon is related to enhanced proliferation of airway …

Airway remodelling refers to the structural changes that occur in both large and small
airways relevant to miscellaneous diseases including asthma. In asthma, airway structural …

Airway remodeling refers to the structural changes that occur in both the large and the small
airways of miscellaneous diseases, including asthma. In asthma, airway structural changes …

In airway diseases such as asthma and COPD, specific structural changes may be
observed, very likely secondary to an underlying inflammatory process. Although it is still …

Structural changes reported in the airways of asthmatics include epithelial fragility, goblet
cell hyperplasia, enlarged submucosal mucus glands, angiogenesis, increased matrix …

During inflammation, leukocytes influx into lung compartments and interact with extracellular
matrix (ECM). Two ECM components, versican and hyaluronan, increase in a range of lung …

Bronchial hyperreactivity has long been recognized as a hallmark of chronic asthma. Less is
known about the prevalence and mechanisms of hyperreactivity in chronic obstructive …

Although asthma is defined in terms of reversibility of airflow obstruction, as the disease
becomes more severe and chronic, it adopts different characteristics, including a degree of …

Versican is a proteoglycan that has many different roles in tissue homeostasis and
inflammation. The biochemical structure comprises four different types of the core protein …