Recent advances in developing small molecules targeting nucleic acid
Nucleic acids participate in a large number of biological processes. However, current
approaches for small molecules targeting protein are incompatible with nucleic acids. On the …
approaches for small molecules targeting protein are incompatible with nucleic acids. On the …
[HTML][HTML] A CRISPR-Cas12a integrated SERS nanoplatform with chimeric DNA/RNA hairpin guide for ultrasensitive nucleic acid detection
Background: CRISPR-Cas12a has been integrated with nanomaterial-based optical
techniques, such as surface-enhanced Raman scattering (SERS), to formulate a powerful …
techniques, such as surface-enhanced Raman scattering (SERS), to formulate a powerful …
Protein–RNA interactions: structural biology and computational modeling techniques
S Jones - Biophysical reviews, 2016 - Springer
RNA-binding proteins are functionally diverse within cells, being involved in RNA-
metabolism, translation, DNA damage repair, and gene regulation at both the transcriptional …
metabolism, translation, DNA damage repair, and gene regulation at both the transcriptional …
Structure, stability and specificity of the binding of ssDNA and ssRNA with proteins
Recognition of single-stranded DNA (ssDNA) or single-stranded RNA (ssRNA) is important
for many fundamental cellular functions. A variety of single-stranded DNA-binding proteins …
for many fundamental cellular functions. A variety of single-stranded DNA-binding proteins …
RmsdXNA: RMSD prediction of nucleic acid-ligand docking poses using machine-learning method
Small molecule drugs can be used to target nucleic acids (NA) to regulate biological
processes. Computational modeling methods, such as molecular docking or scoring …
processes. Computational modeling methods, such as molecular docking or scoring …
Sampling native-like structures of RNA-protein complexes through Rosetta folding and docking
RNA-protein complexes underlie numerous cellular processes including translation,
splicing, and posttranscriptional regulation of gene expression. The structures of these …
splicing, and posttranscriptional regulation of gene expression. The structures of these …
Construction of Histone–Protein Complex Structures by Peptide Growing
BZ Zsidó, B Bayarsaikhan, R Börzsei… - International Journal of …, 2023 - mdpi.com
The structures of histone complexes are master keys to epigenetics. Linear histone peptide
tails often bind to shallow pockets of reader proteins via weak interactions, rendering their …
tails often bind to shallow pockets of reader proteins via weak interactions, rendering their …
Frontiers and Challenges of Computing ncRNAs Biogenesis, Function and Modulation
Non-coding RNAs (ncRNAs), generated from nonprotein coding DNA sequences, constitute
98–99% of the human genome. Non-coding RNAs encompass diverse functional classes …
98–99% of the human genome. Non-coding RNAs encompass diverse functional classes …
Protein-ensemble–RNA docking by efficient consideration of protein flexibility through homology models
Motivation Given the importance of protein–ribonucleic acid (RNA) interactions in many
biological processes, a variety of docking algorithms have been developed to predict the …
biological processes, a variety of docking algorithms have been developed to predict the …
An overview of structural approaches to study therapeutic RNAs
L Mollica, FA Cupaioli, G Rossetti… - Frontiers in Molecular …, 2022 - frontiersin.org
RNAs provide considerable opportunities as therapeutic agent to expand the plethora of
classical therapeutic targets, from extracellular and surface proteins to intracellular nucleic …
classical therapeutic targets, from extracellular and surface proteins to intracellular nucleic …