The intestinal microbiome after traumatic injury

JA Munley, SL Kirkpatrick, GS Gillies, LE Bible… - Microorganisms, 2023 - mdpi.com
The intestinal microbiome plays a critical role in host immune function and homeostasis.
Patients suffering from—as well as models representing—multiple traumatic injuries …

Resistant starches from dietary pulses modulate the gut metabolome in association with microbiome in a humanized murine model of ageing

S Kadyan, G Park, B Wang, P Singh, B Arjmandi… - Scientific Reports, 2023 - nature.com
Emerging evidence suggests that plant-based fiber-rich diets improve ageing-associated
health by fostering a healthier gut microbiome and microbial metabolites. However, such …

Prebiotic mechanisms of resistant starches from dietary beans and pulses on gut microbiome and metabolic health in a humanized murine model of aging

S Kadyan, G Park, P Singh, B Arjmandi… - Frontiers in Nutrition, 2023 - frontiersin.org
Dietary pulses, being a rich source of fiber and proteins, offer an ideal and inexpensive food
choice for older adults to promote gut and metabolic health. However, the prebiotic effects of …

Multicompartmental traumatic injury induces sex-specific alterations in the gut microbiome

JA Munley, LS Kelly, G Park, GS Gillies… - Journal of Trauma …, 2023 - journals.lww.com
BACKGROUND Previous preclinical studies have demonstrated an altered gut microbiome
after traumatic injury; however, the impact of sex on dysbiosis remains unknown. We …

Dietary fiber modulates gut microbiome and metabolome in a host sex-specific manner in a murine model of aging

S Kadyan, G Park, B Wang, R Nagpal - Frontiers in Molecular …, 2023 - frontiersin.org
Emerging evidence reveals the fundamental role of the gut microbiome in human health.
Among various factors regulating our gut microbiome, diet is one of the most indispensable …

Trauma-toxicology: concepts, causes, complications

H Barth, F Worek, D Steinritz, P Papatheodorou… - Naunyn-Schmiedeberg's …, 2024 - Springer
Trauma and toxic substances are connected in several aspects. On the one hand, toxic
substances can be the reason for traumatic injuries in the context of accidental or violent and …

Sex-specific intestinal dysbiosis persists after multicompartmental injury

JA Munley, LS Kelly, G Park, GS Gillies, EE Pons… - Surgery, 2023 - Elsevier
Background Preclinical studies of the gut microbiome after severe traumatic injury have
demonstrated severe dysbiosis in males, with sex-specific microbial differences up to 2 days …

Multicompartmental trauma induces persistent inflammation and organ injury

JA Munley, LS Kelly, GS Gillies, EE Pons… - Journal of Surgical …, 2024 - Elsevier
Introduction Previous preclinical models of multicompartmental injury have investigated its
effects for durations of less than 72 h and the long-term effects have not been defined. We …

Early time-restricted eating improves markers of cardiometabolic health but has no impact on intestinal nutrient absorption in healthy adults

MA Dawson, SN Cheung, MR La Frano, R Nagpal… - Cell Reports …, 2024 - cell.com
Early time-restricted eating (eTRE) improves aspects of cardiometabolic health. Although the
circadian system appears to regulate nutrient absorption, little is known about the effects of …

Nonselective beta blockade enhances gut microbiome diversity in a rodent model of trauma, hemorrhage, and chronic stress

JA Munley, LS Kelly, G Park, EE Pons… - Journal of Trauma …, 2025 - journals.lww.com
BACKGROUND Traumatic injury leads to gut dysbiosis with changes in microbiome diversity
and conversion toward a “pathobiome” signature characterized by a selective …