Haemochromatosis is defined as systemic iron overload of genetic origin, caused by a
reduction in the concentration of the iron regulatory hormone hepcidin, or a reduction in …

The liver orchestrates systemic iron balance by producing and secreting hepcidin. Known as
the iron hormone, hepcidin induces degradation of the iron exporter ferroportin to control …

The iron hormone hepcidin and its receptor and cellular iron exporter ferroportin control the
major fluxes of iron into blood plasma: intestinal iron absorption, the delivery of recycled iron …

Iron is essential for several vital biological processes. Its deficiency or overload drives to the
development of several pathologies. To maintain iron homeostasis, the organism controls …

Bone morphogenetic proteins (BMPs) exhibit broad spectra of biological activities in various
tissues, including bone, cartilage, blood vessels, heart, kidney, neurons, liver and lung …

BACKGROUND: Iron is utilized by several proteins as cofactor for major biological
processes. However, iron may also harm cells by catalyzing the generation of free radicals …

Iron and its homeostasis are intimately tied to the inflammatory response. The adaptation to
iron deficiency, which confers resistance to infection and improves the inflammatory …

Iron deficiency is a common condition increasingly diagnosed and treated by
gastroenterologists. The most common presentation of iron deficiency is anaemia; however …

Anemia is prevalent in patients with chronic kidney disease (CKD) and is associated with
lower quality of life and higher risk of adverse outcomes, including cardiovascular disease …

Anemia of chronic disease (ACD) or anemia of inflammation is prevalent in patients with
chronic infection, autoimmune disease, cancer, and chronic kidney disease. ACD is …