Emerging evidence demonstrates that alcohol dependence is associated with dysregulation
of several neurotransmitters. Alterations in dopamine, glutamate and gamma-aminobutyric …

Alcohol addiction is a chronic relapsing brain disease characterized by an impaired ability to
stop or control alcohol use despite adverse consequences. A main challenge of addiction …

Alzheimer's disease (AD) is a progressive neurodegenerative disorder that represents the
most common cause of dementia in the United States. Although the link between alcohol …

Depression is a well-known risk factor for developing relapse drinking, but the neuronal
mechanisms underlying the interactions between depression and alcohol use disorders …

The majority of neuronal proteins involved in cellular signaling undergo different
posttranslational modifications significantly affecting their functions. One of these …

The commonalities between different phases of stress and alcohol use as well as the high
comorbidity between alcohol use disorders (AUDs) and anxiety disorders suggest common …

Binge-drinking is the most prevalent form of alcohol abuse and while an early life history of
binge-drinking is a significant risk factor for subsequent alcoholism and co-morbid affective …

Alcohol use disorder (AUD) produces cognitive deficits, indicating a shift in prefrontal cortex
(PFC) function. PFC glutamate neurotransmission is mostly mediated by α-amino-3‑hydroxy …

Cognitive impairments, uncontrolled drinking, and neuropathological cortical changes
characterize alcohol use disorder. Dysfunction of the orbitofrontal cortex (OFC), a critical …

Despite recent extensive genomic and genetic studies on behavioral responses to ethanol,
relatively few new therapeutic targets for the treatment of alcohol use disorder have been …