Developments in 177Lu-based radiopharmaceutical therapy and dosimetry

SC George, EJJ Samuel - Frontiers in Chemistry, 2023 - frontiersin.org
177Lu is a radioisotope that has become increasingly popular as a therapeutic agent for
treating various conditions, including neuroendocrine tumors and metastatic prostate …

Radiomics and Artificial Intelligence in Radiotheranostics: a review of applications for Radioligands Targeting somatostatin receptors and prostate-specific membrane …

E Yazdani, P Geramifar, N Karamzade-Ziarati… - Diagnostics, 2024 - mdpi.com
Radiotheranostics refers to the pairing of radioactive imaging biomarkers with radioactive
therapeutic compounds that deliver ionizing radiation. Given the introduction of very …

Quantitative 177Lu SPECT/CT imaging for personalized dosimetry using a ring-shaped CZT-based camera

R Danieli, M Stella, J Leube, J Tran-Gia, C Marin… - EJNMMI physics, 2023 - Springer
Background Dosimetry after radiopharmaceutical therapy with 177Lu (177Lu-RPT) relies on
quantitative SPECT/CT imaging, for which suitable reconstruction protocols are required. In …

Voxel-based dosimetry predicts hepatotoxicity in hepatocellular carcinoma patients undergoing radioembolization with 90Y glass microspheres

M Watanabe, H Grafe, J Theysohn… - Journal of Nuclear …, 2023 - Soc Nuclear Med
Personalized dosimetry holds promise to improve radioembolization treatment outcomes in
hepatocellular carcinoma (HCC) patients. To this end, tolerance absorbed doses for …

An international study of factors affecting variability of dosimetry calculations, part 3: contribution from calculating absorbed dose from time-integrated activity

J Brosch-Lenz, S Kurkowska, E Frey… - Journal of Nuclear …, 2024 - jnm.snmjournals.org
Image-based dosimetry-guided radiopharmaceutical therapy has the potential to
personalize treatment by limiting toxicity to organs at risk and maximizing the therapeutic …

An international study of factors affecting variability of dosimetry calculations, part 2: overall variabilities in absorbed dose

J Brosch-Lenz, S Ke, H Wang, E Frey… - Journal of Nuclear …, 2023 - Soc Nuclear Med
Dosimetry for personalized radiopharmaceutical therapy has gained considerable attention.
Many methods, tools, and workflows have been developed to estimate absorbed dose (AD) …

[PDF][PDF] Artificial Intelligence in Radiotheranostics: A Review of Applications for Radioligands Targeting Somatostatin Receptors and Prostate-Specific Membrane …

E Yazdani, P Geramifar, N Karamzade-Ziarati… - 2024 - researchgate.net
Radiotheranostics refers to the pairing of radioactive imaging biomarkers with radioactive
therapeutic compounds that deliver ionizing radiation. Given the introduction of very …

Nanomaterials in Cancer Diagnosis and Therapy

F Brero, S Gallo - International Journal of Molecular Sciences, 2022 - mdpi.com
Currently, the most commonly used treatments for cancer are surgery, radiotherapy, and
chemotherapy [1–6]. All three methods could lead to damaging normal tissues or the …

Photon effective dose prediction using XGBoost: A machine learning approach for radiological protection

AAA Alghamdi, AZ Aljassir, RO Almuaybid… - Radiation Physics and …, 2025 - Elsevier
Abstract The International Commission on Radiological Protection (ICRP) developed dose
conversion coefficients (DCC) using effective dose calculated for anthropomorphic …

A single-institution experience with 177Lu RPT workflow improvements and qualifying the SPECT/CT imaging for dosimetry

SC George, R Tolakanahalli, S Aguirre, TP Kim… - Frontiers in …, 2024 - frontiersin.org
Background and purpose Implementing any radiopharmaceutical therapy (RPT) program
requires a comprehensive review of system readiness, appropriate workflows, and training …