Purpose of review This review of diffuse intrinsic pontine glioma (DIPG) provides clinical
background, a systematic approach to diagnosis and initial care, and synthesizes historical …

Diffuse intrinsic pontine glioma (DIPG) is a fatal pediatric cancer with limited therapeutic
options. The majority of cases of DIPG exhibit a mutation in histone-3 (H3K27M) that results …

Intradural spinal tumors are rare tumors of the central nervous system. Due to the eloquence
of the spinal cord and its tracts, the compact architecture of the cord and nerves, and the …

Diffuse intrinsic pontine glioma (DIPG) is a universally fatal malignancy of the childhood
central nervous system, with a median overall survival of 9–11 months. We have previously …

Summary The histone H3 K27M mutation has been frequently reported in most diffuse
midline gliomas. However, the relationship between the H3 K27M mutation and clinical …

Diffuse intrinsic pontine glioma (DIPG) is a universally fatal pediatric brainstem tumor
affecting approximately 300 children in the US annually. Median survival is less than 1 year …

Due to the rare incidence of spinal cord astrocytomas, their molecular features remain
unclear. Here, we characterized the landscapes of mutations in H3 K27M, isocitrate …

Glioblastoma (GBM) is the most common and devastating malignant brain tumor in adults.
The mortality rate is very high despite different treatments. New therapeutic targets are …

Pediatric spinal low-grade glioma (LGG) and glioneuronal tumours are rare, accounting for
less 2.8–5.2% of pediatric LGG. New tumour types frequently found in spinal location such …

Intramedullary spinal cord tumors (IMSCTs) are rare neoplasms that have limited treatment
options and are associated with high rates of morbidity and mortality. To better understand …