Adjuvant nivolumab in resected stage IIB/C melanoma: primary results from the randomized, phase 3 CheckMate 76K trial

JM Kirkwood, M Del Vecchio, J Weber, C Hoeller… - Nature Medicine, 2023 - nature.com
Patients with resected stage IIB/C melanoma have high recurrence risk, similar to those with
resected stage IIIA/B disease. The phase 3, double-blind CheckMate 76K trial assessed 790 …

Molecular biomarkers for melanoma screening, diagnosis and prognosis: current state and future prospects

DC Deacon, EA Smith, RL Judson-Torres - Frontiers in Medicine, 2021 - frontiersin.org
Despite significant progress in the development of treatment options, melanoma remains a
leading cause of death due to skin cancer. Advances in our understanding of the genetic …

The status of adjuvant and neoadjuvant melanoma therapy, new developments and upcoming challenges

H Stege, M Haist, U Nikfarjam, M Schultheis, J Heinz… - Targeted …, 2021 - Springer
The global incidence of malignant melanoma, the leading cause of skin cancer death, has
steadily increased in recent years. Surgical excision is the treatment of choice for early-stage …

Lymphangiogenesis-inducing vaccines elicit potent and long-lasting T cell immunity against melanomas

MS Sasso, N Mitrousis, Y Wang, PS Briquez… - Science …, 2021 - science.org
In melanoma, the induction of lymphatic growth (lymphangiogenesis) has long been
correlated with metastasis and poor prognosis, but we recently showed it can synergistically …

Active surveillance of patients who have sentinel node positive melanoma: an international, multi‐institution evaluation of adoption and early outcomes after the …

KK Broman, T Hughes, L Dossett, J Sun, D Kirichenko… - Cancer, 2021 - Wiley Online Library
Background For patients with sentinel lymph node (SLN)‐positive cutaneous melanoma, the
Second Multicenter Selective Lymphadenectomy trial demonstrated equivalent disease …

Common toxicities associated with immune checkpoint inhibitors and targeted therapy in the treatment of melanoma: A systematic scoping review

MD Egeler, M van Leeuwen, I Fraterman… - Critical Reviews in …, 2023 - Elsevier
Introduction This systematic scoping review compares the toxicities experienced by patients
receiving immune checkpoint inhibitors (ICIs) or targeted therapy (TT) for stage III (resected …

The evolution of the sentinel node biopsy in melanoma

A Allard-Coutu, V Dobson, E Schmitz, H Shah… - Life, 2023 - mdpi.com
The growing repertoire of approved immune-checkpoint inhibitors and targeted therapy has
revolutionized the adjuvant treatment of melanoma. While the treatment of primary …

Real-world adherence to nodal surveillance for sentinel lymph node-positive melanoma

KB Montgomery, TA Correya, KK Broman - Annals of surgical oncology, 2022 - Springer
Background Patients with sentinel lymph node-positive (SLN+) melanoma are increasingly
undergoing active nodal surveillance over completion lymph node dissection (CLND) since …

Surveillance of sentinel node-positive melanoma patients who receive adjuvant therapy without undergoing completion lymph node dissection

KK Broman, D Bettampadi, J Pérez-Morales… - Annals of surgical …, 2021 - Springer
Introduction Adjuvant therapy trials required completion lymph node dissection (CLND) for
sentinel lymph node (SLN)-positive melanoma prior to systemic treatment, but nodal …

Contrast mechanisms in pump-probe microscopy of melanin

D Grass, GM Beasley, MC Fischer, MA Selim… - Optics …, 2022 - opg.optica.org
Pump-probe microscopy of melanin in tumors has been proposed to improve diagnosis of
malignant melanoma, based on the hypothesis that aggressive cancers disaggregate …