Metabolism plays an important role in regulating aging at several levels, and metabolic
reprogramming is the main driving force of aging. Due to the different metabolic needs of …

Aging-induced neurodegenerative diseases (NDs) are significantly increasing health
problem worldwide. It has been well documented that oxidative stress is one of the potential …

Spermidine (SPD) is a natural polyamine present in all living organisms and is involved in
the maintenance of cellular homeostasis by inducing autophagy in different model …

Aging inhibits male reproductive function and can have an impact on fertility. This study
elucidated the accelerating role of sodium arsenite (As 3+) on D-galactose-induced …

The brain− gut− microbiome (BGM) axis affects host bioinformation. N-3 polyunsaturated
fatty acids (PUFAs) alleviate cognitive impairment and depression in older adults. This study …

Osteosarcopenic obesity (OSO) has been associated with increase immobility, falls,
fractures, and other dysfunctions, which could increase mortality risk during aging. However …

Mitochondria are the main sources of energy production for muscle tissues, including
skeletal, cardiac, or smooth muscle, to support their activities. Mitochondrial dysfunction and …

Aging-related muscle loss is a hallmark of aging and is the cause of some negative
outcomes. An optimized diet and supplements have a positive effect in slowing down the …

Chronic D-galactose administration induces accelerated aging in rodents. The aim of the
study was to find by in vivo 31 P MRS suitable markers of early stages of brain degeneration …

Recent evidence suggests that the gut plays a vital role in the development and progression
of Alzheimer's disease (AD) by triggering systemic inflammation and oxidative stress. The …