The sirtuin family in health and disease

QJ Wu, TN Zhang, HH Chen, XF Yu, JL Lv… - … and Targeted Therapy, 2022 - nature.com
Sirtuins (SIRTs) are nicotine adenine dinucleotide (+)-dependent histone deacetylases
regulating critical signaling pathways in prokaryotes and eukaryotes, and are involved in …

Overnutrition induced cognitive impairment: insulin resistance, gut-brain axis, and neuroinflammation

Q Zhang, K Jin, B Chen, R Liu, S Cheng… - Frontiers in …, 2022 - frontiersin.org
Overnutrition-related obesity has become a worldwide epidemic, and its prevalence is
expected to steadily rise in the future. It is widely recognized that obesity exerts negative …

The effects of Ellagic acid supplementation on neurotrophic, inflammation, and oxidative stress factors, and indoleamine 2, 3-dioxygenase gene expression in multiple …

G Hajiluian, SJ Karegar, F Shidfar, N Aryaeian… - Phytomedicine, 2023 - Elsevier
Background Depression is one of the most common psychological disorders among multiple
sclerosis (MS) patients that characterized as the first symptoms. Ellagic acid is a natural …

Influences of Microwave-Assisted Extraction Parameters on Antioxidant Activity of the Extract from Akebia trifoliata Peels

M Luo, DD Zhou, A Shang, RY Gan, HB Li - Foods, 2021 - mdpi.com
Akebia trifoliata is a fruit with rich nutritional properties, and its peel is produced as a by-
product. In this research, we investigated the influences of microwave-assisted extraction …

Role of Bioactive Compounds in Obesity: Metabolic Mechanism Focused on Inflammation

E Ramírez-Moreno, J Arias-Rico, RC Jiménez-Sánchez… - Foods, 2022 - mdpi.com
Obesity is a disease characterized by an inflammatory process in the adipose tissue due to
diverse infiltrated immune cells, an increased secretion of proinflammatory molecules, and a …

[HTML][HTML] Apigenin targets fetuin-A to ameliorate obesity-induced insulin resistance

MC Hsu, CH Chen, MC Wang, WH Chen… - … Journal of Biological …, 2024 - ncbi.nlm.nih.gov
Fetuin-A, a hepatokine secreted by hepatocytes, binds to insulin receptors and consequently
impairs the activation of the insulin signaling pathway, leading to insulin resistance …

An evaluation of the anti-inflammatory effects of a thai traditional polyherbal recipe TPDM6315 in LPS-Induced RAW264. 7 macrophages and TNF-α-induced 3T3-L1 …

P Subin, P Sabuhom, A Naladta, P Luecha… - Current Issues in …, 2023 - mdpi.com
TPDM6315 is an antipyretic Thai herbal recipe that contains several herbs with anti-
inflammatory and anti-obesity activities. This study aimed to investigate the anti-inflammatory …

Ellagic acid as potential therapeutic compound for diabetes and its complications: a systematic review from bench to bed

H Ghazaee, A Raouf Sheibani, H Mahdian… - Naunyn-Schmiedeberg's …, 2024 - Springer
Diabetes mellitus (DM) is a worldwide-concerning disease with a rising prevalence. There
are many ongoing studies aimed at finding new and effective treatments. Ellagic acid (EA) is …

Potential roles of ellagic acid on metabolic variables in diabetes mellitus: A systematic review

V Maleki, S Abbaszadeh… - Clinical and …, 2023 - Wiley Online Library
Diabetes mellitus is a widespread endocrine disorder globally. Due to its antioxidant and
anti‐inflammatory properties, ellagic acid has the potential to improve the metabolic effects …

The value of proteomic studies of the latest markers of kidney damage in the urine to assess the course, progression and complications in patients with CKD

LD Denova - Kidneys, 2022 - kidneys.zaslavsky.com.ua
Сhronic kidney Disease (CKD) is the cause of both morbidity and mortality worldwide. In
Ukraine, 12% of the population is diagnosed with CKD. Significantly worsen the quality of …