Nitric oxide (NO) is a small free radical with critical signaling roles in physiology and
pathophysiology. The generation of sufficient NO levels to regulate the resistance of the …

The NADPH oxidase (Nox) family of superoxide (O2−) and hydrogen peroxide (H2O2)-
producing proteins has emerged as an important source of reactive oxygen species (ROS) …

Reactive oxygen species (ROS) are recently proposed to be involved in tumor metastasis
which is a complicated processes including epithelial–mesenchymal transition (EMT) …

Reactive oxygen and nitrogen species are produced in a wide range of physiological
reactions that, at low concentrations, play essential roles in living organisms. There is a …

Smooth muscle cell migration occurs during vascular development, in response to vascular
injury, and during atherogenesis. Many proximal signals and signal transduction pathways …

Rational target therapy of cancer would benefit from the identification of new targets that can
be easily inhibited by small molecules. An increasing amount of evidence hints at 3 …

Rationale: NADPH oxidases (Noxes) regulate vascular physiology and contribute to the
pathogenesis of vascular disease. In vascular smooth muscle cells (VSMCs), the …

Reactive oxygen species (ROS) are natural byproducts of oxygen metabolism in the cell. At
physiological levels, they play a vital role in cell signaling. However, high ROS levels cause …

There is growing evidence that oxidative stress contributes to hypertension. Oxidative stress
can precede the development of hypertension. In almost all models of hypertension, there is …

Oxidative stress represents excessive intracellular levels of reactive oxygen species (ROS),
which plays a major role in the pathogenesis of cardiovascular disease. Besides having a …