TRPM8 channels: Advances in structural studies and pharmacological modulation
C Izquierdo, M Martín-Martínez… - International Journal of …, 2021 - mdpi.com
The transient receptor potential melastatin subtype 8 (TRPM8) is a cold sensor in humans,
activated by low temperatures (> 10,< 28° C), but also a polymodal ion channel, stimulated …
activated by low temperatures (> 10,< 28° C), but also a polymodal ion channel, stimulated …
Therapeutic potential of TRPM8 channels in cancer treatment
SV Ochoa, Z Casas, SL Albarracín… - Frontiers in …, 2023 - frontiersin.org
Cancer is a multifactorial process associated with changes in signaling pathways leading to
cell cycle variations and gene expression. The transient receptor potential melastatin 8 …
cell cycle variations and gene expression. The transient receptor potential melastatin 8 …
TRPM8 indicates poor prognosis in colorectal cancer patients and its pharmacological targeting reduces tumour growth in mice by inhibiting Wnt/β‐catenin signalling
Abstract Background and Purpose Transient receptor potential melastatin type‐8 (TRPM8) is
a cold‐sensitive cation channel protein belonging to the TRP superfamily of ion channels …
a cold‐sensitive cation channel protein belonging to the TRP superfamily of ion channels …
Grading differentiation in cutaneous squamous cell carcinoma: a review of the literature
C Diede, T Walker, DR Carr, KT Shahwan - Archives of Dermatological …, 2024 - Springer
Poor differentiation is strongly associated with poor outcomes in cutaneous squamous cell
carcinoma (CSCC). In addition, the National Comprehensive Cancer Network (NCCN) …
carcinoma (CSCC). In addition, the National Comprehensive Cancer Network (NCCN) …
The association between TRP channels expression and Clinicopathological characteristics of patients with pancreatic adenocarcinoma
NR Chelaru, A Chiosa, A Sorop, A Spiridon… - International Journal of …, 2022 - mdpi.com
Pancreatic adenocarcinoma (PDAC) has low survival rates worldwide due to its tendency to
be detected late and its characteristic desmoplastic reaction, which slows the use of targeted …
be detected late and its characteristic desmoplastic reaction, which slows the use of targeted …
[HTML][HTML] Tegaserod maleate exhibits antileukemic activity by targeting TRPM8
X Xie, W Yang, W Zhang, Y Qiu, Z Qiu, H Wang… - Biomedicine & …, 2022 - Elsevier
To identify therapeutic targets in acute myeloid leukemia (AML), we conducted growth
inhibition screens of 2040 small molecules from a library of FDA-approved drugs using a …
inhibition screens of 2040 small molecules from a library of FDA-approved drugs using a …
[HTML][HTML] Antagonism of the transient receptor potential melastatin‑2 channel leads to targeted antitumor effects in primary human malignant melanoma cells
SG McKamey, LR Jira, CM Tweed… - International …, 2022 - spandidos-publications.com
Melanoma continues to be the most aggressive and devastating form of skin cancer for
which the development of novel therapies is required. The present study aimed to determine …
which the development of novel therapies is required. The present study aimed to determine …
Trpm8 channels: Advances in structural studies and pharmacological modulation
C Izquierdo García, M Martín-Martínez… - 2021 - digital.csic.es
The transient receptor potential melastatin subtype 8 (TRPM8) is a cold sensor in humans,
activated by low temperatures (> 10,< 28° C), but also a polymodal ion channel, stimulated …
activated by low temperatures (> 10,< 28° C), but also a polymodal ion channel, stimulated …
TRPM2 Channels: A Potential Therapeutic Target in Melanoma?
HM Foster, MKN Carle, LR Jira, DW Koh - International Journal of …, 2023 - mdpi.com
The transient receptor potential, the melastatin (TRPM) subfamily, which consists of eight
known members, appears to have significant importance in melanoma progression …
known members, appears to have significant importance in melanoma progression …