Abstract NF-E2-related factor 2 (Nrf2) protein is a basic-region leucine zipper transcription
factor that defends against endogenous or exogenous stressors. By inducing several …

A growing awareness of the mechanisms by which phytochemicals can influence upstream
endogenous cellular defence processes has led to intensified research into their potential …

Research into human biotransformation and elimination systems continues to evolve.
Various clinical and in vivo studies have been undertaken to evaluate the effects of foods …

Reactive oxygen species (ROS) have been correlated with almost every human disease. Yet
clinical exploitation of these hypotheses by pharmacological modulation of ROS has been …

Epilepsy therapy is based on antiseizure drugs that treat the symptom, seizures, rather than
the disease and are ineffective in up to 30% of patients. There are no treatments for …

The recognition that food‐derived nonnutrient molecules can modulate gene expression to
influence intracellular molecular mechanisms has seen the emergence of the fields of …

Background Nuclear factor erythroid 2-related factor (Nrf2), a stress-activated transcription
factor, has been documented to induce a defense mechanism against oxidative stress …

Significance: All cells must maintain a balance between oxidants and reductants, while
allowing for fluctuations in redox states triggered by signaling, altered metabolic flow, or …

Significance: Sulforaphane, produced by the hydrolytic conversion of glucoraphanin after
ingestion of cruciferous vegetables, particularly broccoli and broccoli sprouts, has been …

Environmental risk factors, including noise, air pollution, chemical agents, ultraviolet
radiation (UVR) and mental stress have a considerable impact on human health. Oxidative …