11beta-Hydroxysteroid dehydrogenases (11beta-HSDs) interconvert active corticosterone
and inert 11-dehydrocorticosterone. In tissue homogenates, 11beta-HSD type 1 (11beta …

Type 1 diabetes mellitus (T1DM) results from death of insulin-secreting β cells mediated by
self-immune cells, and the consequent inability of the body to maintain insulin levels for …

The problem of pancreas donor shortage could be addressed through in vitro islet-cell
proliferation prior to transplantation into diabetic patients. Therefore, we set out to evaluate …

Cellular models and culture conditions for in vitro expansion of insulin-producing cells
represent a key element to develop cell therapy for diabetes. Initial evidence that human β …

Background: Nestin, an intermediate filament (IF) protein, is expressed in proliferating
progenitor cells of developmental and regenerating tissues, and is identified as a …

Diabetes mellitus represents a serious public health problem owing to its global prevalence
in the last decade. The causes of this metabolic disease include dysfunction and/or …

Overexpression of bovine growth hormone (bGH) in transgenic (PEPCK-bGH) mice induces
resistance to insulin, which is compensated by a major increase in insulin levels. In these …

Bone marrow mesenchymal stem cells (BMSCs) have been reported to possess low
immunogenicity and cause immunosuppression of recipients when allografted. They can …

The present study examined whether nestin+ neural-like stem cells detected in the scar
tissue of rats 1 week after myocardial infarction (MI) were derived from bone marrow and/or …

Glucagon-like peptide-1 (GLP-1) is an insulinotropic hormone expressed by alternative post-
translational processing of proglucagon in the intestines, endocrine pancreas, and brain …