Organization of vestibular circuits for postural control in zebrafish

Z Liu, MW Bagnall - Current Opinion in Neurobiology, 2023 - Elsevier
Most animals begin controlling their posture, or orientation with respect to gravity, at an early
stage in life. Posture is vital for locomotor function. Even animals like fish, which are capable …

Future pharmacotherapy for sensorineural hearing loss by protection and regeneration of auditory hair cells

M Matsunaga, T Nakagawa - Pharmaceutics, 2023 - mdpi.com
Sensorineural hearing loss has been a global burden of diseases for decades. However,
according to recent progress in experimental studies on hair cell regeneration and …

The forkhead transcription factor Foxj1 controls vertebrate olfactory cilia biogenesis and sensory neuron differentiation

D Rayamajhi, M Ege, K Ukhanov, C Ringers… - PLoS …, 2024 - journals.plos.org
In vertebrates, olfactory receptors localize on multiple cilia elaborated on dendritic knobs of
olfactory sensory neurons (OSNs). Although olfactory cilia dysfunction can cause anosmia …

Differential expression of mechanotransduction complex genes in auditory/vestibular hair cells in zebrafish

ET Smith, P Sun, SK Yu, DW Raible… - Frontiers in Molecular …, 2023 - frontiersin.org
Ciliated sensory cells such as photo-and olfactory receptors employ multiple types of opsins
or hundreds of unique olfactory G-protein coupled receptors to respond to various …

Complexes of vertebrate TMC1/2 and CIB2/3 proteins form hair-cell mechanotransduction cation channels

APJ Giese, WH Weng, KS Kindt, HHV Chang… - eLife, 2025 - elifesciences.org
Calcium and integrin-binding protein 2 (CIB2) and CIB3 bind to transmembrane channel-like
1 (TMC1) and TMC2, the pore-forming subunits of the inner-ear mechano-electrical …

Transmembrane channel-like (Tmc) subunits contribute to frequency sensitivity in the zebrafish utricle

P Sun, E Smith, T Nicolson - Journal of Neuroscience, 2024 - Soc Neuroscience
Information about dynamic head motion is conveyed by a central “striolar” zone of vestibular
hair cells and afferent neurons in the inner ear. How vestibular hair cells are tuned to …

Transdifferentiation is temporally uncoupled from progenitor pool expansion during hair cell regeneration in the zebrafish inner ear

MO Beaulieu, ED Thomas, DW Raible - Development, 2024 - journals.biologists.com
Death of mechanosensory hair cells in the inner ear is a common cause of auditory and
vestibular impairment in mammals, which have a limited ability to regrow these cells after …

Long-range Atoh1 enhancers maintain competency for hair cell regeneration in the inner ear

T Shi, Y Kim, J Llamas, X Wang, P Fabian… - Proceedings of the …, 2024 - pnas.org
During tissue regeneration, lineage-related cells can switch their fate to replace missing
cells. This cell plasticity is particularly prominent in more regenerative vertebrates such as …

Vestibular physiology and function in zebrafish

S Baeza-Loya, DW Raible - Frontiers in Cell and Developmental …, 2023 - frontiersin.org
The vestibular system of the inner ear provides information about head motion and spatial
orientation relative to gravity to ensure gaze stability, balance, and postural control …

Cross-species analyses of thymic mimetic cells reveal evolutionarily ancient origins and both conserved and species-specific elements

BD Huisman, DA Michelson, SA Rubin, K Kohlsaat… - Immunity, 2024 - cell.com
Thymic mimetic cells are molecular hybrids between medullary-thymic-epithelial cells
(mTECs) and diverse peripheral cell types. They are involved in eliminating autoreactive T …