Although acute or chronic inflammation is a common component of many clinical disorders,
the underlying processes can be highly distinct. In recent years, the complement system has …

The complement cascade is an ancient immune‐surveillance system that not only provides
protection from pathogen invasion but has also evolved to participate in physiological …

In the last decade, transplantation across previously incompatible barriers has increasingly
become popular because of organ donor shortage, availability of better methods of detecting …

With the awareness that immune-inflammatory cross-talk is at the heart of many disorders,
the desire for novel immunomodulatory strategies in the therapy of such diseases has grown …

Antibody-mediated rejection (AMR) is typically treated with plasmapheresis (PP) and
intravenous immunoglobulin (standard of care; SOC); however, there is an unmet need for …

Solid organ transplantation is a curative therapy for hundreds of thousands of patients with
end-stage organ failure. However, long-term outcomes have not improved, and nearly half of …

Sensitization, defined as the presence of circulating antibodies, presents challenges for
heart transplant recipients and physicians. When present, sensitization can limit a …

Background Antibody-mediated rejection (AMR) is a severe form of rejection, mediated
primarily by antibody-dependent complement (C) activation. C1 inhibitor (C1-INH, Berinert) …

Increasing evidence indicates an integral role for the complement system in the deleterious
inflammatory reactions that occur during critical phases of the transplantation process, such …

Complement inhibitors have not been thoroughly evaluated in the treatment of acute
antibody-mediated rejection (ABMR). We performed a prospective, single-arm pilot study to …