The interaction between microglia and astrocytes exhibits a relatively balanced state in
order to maintain homeostasis in the healthy central nervous system (CNS). Disease stimuli …

Since their original discovery, type I interferons (IFN-Is) have been closely associated with
antiviral immune responses. However, their biological functions go far beyond this role, with …

Traumatic brain injury (TBI) is a leading cause of morbidity and mortality. The innate and
adaptive immune responses play an important role in the pathogenesis of TBI. Gamma-delta …

Traumatic brain injury (TBI) is associated with chronic psychiatric complications and
increased risk for development of neurodegenerative pathology. Aged individuals account …

Traumatic brain injury (TBI) is associated with an increased risk of cognitive, psychiatric, and
neurodegenerative complications that may develop after injury. Increased microglial …

Aging adversely affects inflammatory processes in the brain, which has important
implications in the progression of neurodegenerative disease. Following traumatic brain …

Traumatic brain injury (TBI) is a complex condition that can resolve over time but all too often
leads to persistent symptoms, and the risk of poor patient outcomes increases with aging …

Glioblastoma is an incurable brain malignancy. By the time of clinical diagnosis, these
tumours exhibit a degree of genetic and cellular heterogeneity that provides few clues to the …

Traumatic brain injury (TBI) often results in prolonged or permanent brain dysfunction with
over 2.8 million affected annually in the US, including over 56,000 deaths, with over 5 million …

Traumatic brain injury (TBI) is a leading cause of chronic brain impairment and results in a
robust, but poorly understood, neuroinflammatory response that contributes to the long-term …