Cancer immunotherapies targeting adaptive immune checkpoints have substantially
improved patient outcomes across multiple metastatic and treatment-refractory cancer types …

BACKGROUND: Photodynamic therapy (PDT) is an established, minimally invasive
treatment for specific types of cancer. During PDT, reactive oxygen species (ROS) are …

Nanomaterial-synergized photodynamic therapy (PDT) and photothermal therapy (PTT), as
efficient and non-invasive treatment modalities, have shown significant advantages in …

The endoplasmic reticulum (ER) and mitochondria cannot be considered as static structures,
as they intimately communicate, forming very dynamic platforms termed mitochondria …

Macrophage phagocytosis of tumor cells mediated by CD47-specific blocking antibodies
has been proposed to be the major effector mechanism in xenograft models. Here, using …

The immune system deploys a multitude of innate and adaptive mechanisms not only to
ward off pathogens but also to prevent malignant transformation (“immune surveillance”) …

Chemotherapy has been a conventional paradigm for cancer treatment, and multifarious
chemotherapeutic drugs have been widely employed for decades with significant …

Immunotherapy has revolutionized oncology remarkably and gained great improvements in
cancer therapy. However, tumor immunotherapy still encounters serious challenges …

The observation that a subset of cancer patients show evidence for spontaneous CD8+ T
cell priming against tumor-associated antigens has generated renewed interest in the innate …

Immunotherapies based on T cells have gained significant success in the treatment of
diverse cancers, however, several limitations also exist, including low response, acquired …