Zinc toxicity: understanding the limits

H Schoofs, J Schmit, L Rink - Molecules, 2024 - mdpi.com
Zinc, a vital trace element, holds significant importance in numerous physiological
processes within the body. It participates in over 300 enzymatic reactions, metabolic …

Excitotoxicity: still hammering the ischemic brain in 2020

DW Choi - Frontiers in neuroscience, 2020 - frontiersin.org
Interest in excitotoxicity expanded following its implication in the pathogenesis of ischemic
brain injury in the 1980s, but waned subsequent to the failure of N-methyl-D-aspartate …

The essential toxin: impact of zinc on human health

LM Plum, L Rink, H Haase - … journal of environmental research and public …, 2010 - mdpi.com
Compared to several other metal ions with similar chemical properties, zinc is relatively
harmless. Only exposure to high doses has toxic effects, making acute zinc intoxication a …

Glutamate receptors, neurotoxicity and neurodegeneration

A Lau, M Tymianski - Pflügers Archiv-European Journal of Physiology, 2010 - Springer
Glutamate excitotoxicity is a hypothesis that states excessive glutamate causes neuronal
dysfunction and degeneration. As glutamate is a major excitatory neurotransmitter in the …

Synthesis, optimization and applications of ZnO/polymer nanocomposites

D Ponnamma, JJ Cabibihan, M Rajan… - Materials Science and …, 2019 - Elsevier
Polymer composites have established an excellent position among the technologically
essential materials because of their wide range of applications. An enormous research …

Copper, iron and zinc in Alzheimer's disease senile plaques

MA Lovell, JD Robertson, WJ Teesdale… - Journal of the …, 1998 - Elsevier
Concentrations of copper (Cu), iron (Fe) and zinc (Zn) were measured in the rims and cores
of senile plaques (SP) and in the neuropil of the amygdala of nine Alzheimer's disease (AD) …

The neurobiology of zinc in health and disease

CJ Frederickson, JY Koh, AI Bush - Nature Reviews Neuroscience, 2005 - nature.com
The use of zinc in medicinal skin cream was mentioned in Egyptian papyri from 2000 BC (for
example, the Smith Papyrus), and zinc has apparently been used fairly steadily throughout …

Zinc in the physiology and pathology of the CNS

SL Sensi, P Paoletti, AI Bush, I Sekler - Nature reviews neuroscience, 2009 - nature.com
The past few years have witnessed dramatic progress on all frontiers of zinc neurobiology.
The recent development of powerful tools, including zinc-sensitive fluorescent probes …

[HTML][HTML] Importance of zinc in the central nervous system: the zinc-containing neuron

CJ Frederickson, SW Suh, D Silva, CJ Frederickson… - The Journal of …, 2000 - Elsevier
Zinc is essential to the structure and function of myriad proteins, including regulatory,
structural and enzymatic. It is estimated that up to 1% of the human genome codes for zinc …

The role of zinc in selective neuronal death after transient global cerebral ischemia

JY Koh, SW Suh, BJ Gwag, YY He, CY Hsu, DW Choi - Science, 1996 - science.org
Zinc is present in presynaptic nerve terminals throughout the mammalian central nervous
system and likely serves as an endogenous signaling substance. However, excessive …