Ischemic stroke is the leading cause of human disability and mortality in the world. The main
problem in stroke therapy is the search of efficient neuroprotector capable to rescue neurons …

Abstract Ischemia-reperfusion (I/R) injury paradoxically occurs during reperfusion following
ischemia, exacerbating the initial tissue damage. The limited understanding of the intricate …

Brain disorders are characterized by the progressive loss of structure and function of the
brain as a consequence of progressive degeneration and/or death of nerve cells. Aging is a …

The Wnt/β-catenin or Wnt canonical pathway controls multiple biological processes
throughout development and adult life. Growing evidences have suggested that …

Insulin-like growth factor (IGF) signaling greatly impacts the development and growth of the
central nervous system (CNS). IGF-I and IGF-II, two ligands of the IGF system, exert a wide …

Besides the classical ones (support/protection, hematopoiesis, storage for calcium, and
phosphate) multiple roles emerged for bone tissue, definitively making it an organ …

Stroke is one of the leading causes of mortality, and survivors experience serious
neurological and motor behavioral deficiencies. Following a cerebral ischemic event …

Extensive evidence supports a central role for amyloid-β (Aβ) in the pathogenesis of
Alzheimer's disease (AD). Synaptic loss mediated by Aβ in early stages of the disease might …

Synapse degeneration occurs early in neurodegenerative diseases and correlates strongly
with cognitive decline in Alzheimer's disease (AD). The molecular mechanisms that trigger …

The roles of Wnts in neural development, synaptogenesis, and cancer are generally well
characterized. Nonetheless, evidence exists that interactions between the immune and …