Mutual information (MI) minimization has gained considerable interests in various machine
learning tasks. However, estimating and minimizing MI in high-dimensional spaces remains …

Major computational challenges exist in relation to the collection, curation, processing and
analysis of large genomic and imaging datasets, as well as the simulation of larger and …

Transposable elements (TEs) produce structural variants and are considered an important
source of genetic diversity. Notably, TE-gene fusion transcripts, ie chimeric transcripts, have …

O-Methyltransferases (OMTs) play important roles in antitumor lignan biosynthesis. To date,
six OMTs catalyzing the methylation of dibenzylbutyrolactone lignans as biosynthetic …

Correlated mutations between residue pairs in evolutionarily related proteins arise from
constraints needed to maintain a functional and stable protein. Identifying these inter-related …

Motivation High-content imaging screens provide a cost-effective and scalable way to
assess cell states across diverse experimental conditions. The analysis of the acquired …

The Gly-Asp-Ser-Leu (GDSL) motif of esterase/lipase family proteins (GELPs) generally
exhibit esterase activity, whereas transferase activity is markedly preferred in several …

Robust, flexible and fast software to read, write and manipulate macromolecular structures is
a prerequisite for productively doing structural bioinformatics. We present BioStructures. jl …

The analysis of evolutionary information in a protein family, such as conservation and
covariation, is often linked to its structural information. Multiple sequence alignments of …

Intrinsically disordered proteins/regions (IDPs/IDRs) are crucial components of the cell, they
are highly abundant and participate ubiquitously in a wide range of biological functions …