Cancer has become a global health hazard accounting for 10 million deaths in the year
2020. Although different treatment approaches have increased patient overall survival …

Autophagy, a process of cellular self-digestion, delivers intracellular components including
superfluous and dysfunctional proteins and organelles to the lysosome for degradation and …

Lysosomal biogenesis plays a vital role in cell fate. Under certain conditions, excessive
lysosomal biogenesis leads to susceptibility for lysosomal membrane permeabilization …

Autophagy is a catabolic process that captures cellular waste and degrades them in the
lysosome. The main functions of autophagy are quality control of cytosolic proteins and …

Simple Summary Tumor recurrence still represents a major clinical challenge for cancer
patients. Cancer cells may undergo a dormant state for long times before re-emerging. Both …

Autophagy is a lysosome‐mediated self‐degradation process of central importance for
cellular quality control. It also provides macromolecule building blocks and substrates for …

Tumors not only consist of cancerous cells, but they also harbor several normal-like cell
types and non-cellular components. Carcinoma-associated fibroblasts (CAFs) are one of …

Despite conventional treatment options including chemoradiation, patients with the most
aggressive primary brain tumor, glioblastoma multiforme (GBM), experience an average …

Autophagy is a key cellular process, which exists in many tumors and plays dual roles in
tumor promotion and suppression. However, the role and mechanism of aberrant autophagy …

Dormant cancer cells account for cancer recurrence, distant metastasis and drug resistance
which lead to poor prognosis in colorectal cancer (CRC). However, little is known about the …