Revisiting recent unusual drug-DNA complex structures: implications for cancer and neurological disease diagnostics and therapeutics
DNA plays a crucial role in various biological processes such as protein production,
replication, recombination etc. by adopting different conformations. Targeting these …
replication, recombination etc. by adopting different conformations. Targeting these …
[HTML][HTML] Targeted oligonucleotides for treating neurodegenerative tandem repeat diseases
R Zain, CIE Smith - Neurotherapeutics, 2019 - Elsevier
Nucleotide repeat disorders encompass more than 30 diseases, most of which show
dominant inheritance, such as Huntington's disease, spinocerebellar ataxias, and myotonic …
dominant inheritance, such as Huntington's disease, spinocerebellar ataxias, and myotonic …
Atypical structures of GAA/TTC trinucleotide repeats underlying Friedreich's ataxia: DNA triplexes and RNA/DNA hybrids
Expansion of the GAA/TTC repeats in the first intron of the FXN gene causes Friedreich's
ataxia. Non-canonical structures are linked to this expansion. DNA triplexes and R-loops are …
ataxia. Non-canonical structures are linked to this expansion. DNA triplexes and R-loops are …
Novel eGZ-motif formed by regularly extruded guanine bases in a left-handed Z-DNA helix as a major motif behind CGG trinucleotide repeats
The expansion of d (CGG) trinucleotide repeats (TRs) lies behind several important
neurodegenerative diseases. Atypical DNA secondary structures have been shown to …
neurodegenerative diseases. Atypical DNA secondary structures have been shown to …
Structure and Dynamics of DNA and RNA Double Helices Formed by d (CTG), d (GTC), r (CUG), and r (GUC) Trinucleotide Repeats and Associated DNA–RNA …
Myotonic dystrophy type 1 is the most frequent form of muscular dystrophy in adults caused
by an abnormal expansion of the CTG trinucleotide. Both the expanded DNA and the …
by an abnormal expansion of the CTG trinucleotide. Both the expanded DNA and the …
Structural basis for targeting T: T mismatch with triaminotriazine-acridine conjugate induces a U-shaped head-to-head four-way junction in CTG repeat DNA
The potent DNA-binding compound triaminotriazine-acridine conjugate (Z1) functions by
targeting T: T mismatches in CTG trinucleotide repeats that are responsible for causing …
targeting T: T mismatches in CTG trinucleotide repeats that are responsible for causing …
Frustration between preferred states of complementary trinucleotide repeat DNA hairpins anticorrelates with expansion disease propensity
DNA trinucleotide repeat (TRs) expansion beyond a threshold often results in human
neurodegenerative diseases. The mechanisms causing expansions remain unknown …
neurodegenerative diseases. The mechanisms causing expansions remain unknown …
Structural and dynamical characterization of DNA and RNA quadruplexes obtained from the GGGGCC and GGGCCT hexanucleotide repeats associated with C9FTD …
A (GGGGCC) hexanucleotide repeat (HR) expansion in the C9ORF72 gene has been
considered the major cause behind both frontotemporal dementia and amyotrophic lateral …
considered the major cause behind both frontotemporal dementia and amyotrophic lateral …
Molecular conformations and dynamics of nucleotide repeats associated with neurodegenerative diseases: double helices and CAG hairpin loops
Pathogenic DNA secondary structures have been identified as a common and causative
factor for expansion in trinucleotide, hexanucleotide, and other simple sequence repeats …
factor for expansion in trinucleotide, hexanucleotide, and other simple sequence repeats …
DNA base pair mismatches induce structural changes and alter the free-energy landscape of base flip
A Kingsland, L Maibaum - The Journal of Physical Chemistry B, 2018 - ACS Publications
Double-stranded DNA may contain mismatched base pairs beyond the Watson–Crick pairs,
guanine–cytosine and adenine–thymine. Such mismatches bear adverse consequences for …
guanine–cytosine and adenine–thymine. Such mismatches bear adverse consequences for …