Targeting cell signaling in allergic asthma

SS Athari - Signal transduction and targeted therapy, 2019 - nature.com
Asthma is chronic inflammation of the airways characterized by airway hyper-
responsiveness, wheezing, cough, and dyspnea. Asthma affects> 350 million people …

Airway smooth muscle in airway reactivity and remodeling: what have we learned?

YS Prakash - American Journal of Physiology-Lung Cellular …, 2013 - journals.physiology.org
It is now established that airway smooth muscle (ASM) has roles in determining airway
structure and function, well beyond that as the major contractile element. Indeed, changes in …

Anti-inflammatory activity of IL-37 in asthmatic children: Correlation with inflammatory cytokines TNF-α, IL-β, IL-6 and IL-17A

R Charrad, A Berraïes, B Hamdi, J Ammar, K Hamzaoui… - Immunobiology, 2016 - Elsevier
Background The aim of this study was to assess interleukin (IL)-37 production in asthmatic
children in serum and induced sputum and to look to the impact of IL-37 on pro-inflammatory …

Increased airway smooth muscle in preschool wheezers who have asthma at school age

R O'Reilly, N Ullmann, S Irving, CJ Bossley… - Journal of Allergy and …, 2013 - Elsevier
BACKGROUND: Increased airway smooth muscle (ASM) is a feature of established asthma
in schoolchildren, but nothing is known about ASM in preschool wheezers. OBJECTIVE: We …

[HTML][HTML] LncRNAs BCYRN1 promoted the proliferation and migration of rat airway smooth muscle cells in asthma via upregulating the expression of transient receptor …

XY Zhang, LX Zhang, CJ Tian, XY Tang… - American journal of …, 2016 - ncbi.nlm.nih.gov
Background: Long noncoding RNAs (lncRNAs) played important roles in several biological
processes through regulating the expression of protein. However, the function of lncRNA …

IL-17RA signaling in airway inflammation and bronchial hyperreactivity in allergic asthma

CR Willis, L Siegel, A Leith, D Mohn… - American journal of …, 2015 - atsjournals.org
Asthma is a heterogeneous disease characterized by airway inflammation and
hyperreactivity. IL-17 receptor A (IL-17RA) is a shared receptor subunit required for activity …

α-Asarone suppresses the proliferation and migration of ASMCs through targeting the lncRNA-PVT1/miR-203a/E2F3 signal pathway in RSV-infected rats

X Yu, Z Zhe, B Tang, S Li, L Tang, Y Wu… - Acta biochimica et …, 2017 - academic.oup.com
Asthma is a chronic inflammatory pulmonary disease and respiratory syncytial virus (RSV)
infection is a common cause of lower respiratory tract illness in infants and young children. α …

Remodeling, inflammation and airway responsiveness in early childhood asthma

K Malmström, AS Pelkonen… - Current opinion in allergy …, 2013 - journals.lww.com
Remodeling, inflammation and airway responsiveness in early... : Current Opinion in Allergy
and Clinical Immunology Remodeling, inflammation and airway responsiveness in early …

Long non-coding RNA TCF7 contributes to the growth and migration of airway smooth muscle cells in asthma through targeting TIMMDC1/Akt axis

M Fan, J Xu, Q Xiao, F Chen, X Han - Biochemical and biophysical …, 2019 - Elsevier
Abstract Background Long noncoding RNAs (lncRNAs) have been revealed to participate in
cellular biological processes in multiple diseases, including asthma. Nevertheless, the role …

Особенности молекулярных механизмов патогенеза бронхиальной астмы в сочетании с полипозным риносинуситом

ОМ Курбачева, МЕ Дынева… - …, 2021 - journal.pulmonology.ru
Аннотация В настоящее время бронхиальная астма (БА) в сочетании с полипозным
риносинуситом (ПРС) рассматривается как отдельный фенотип, где дизрегуляция про …