Knee osteoarthritis: a review of pathogenesis and state-of-the-art non-operative therapeutic considerations
Being the most common musculoskeletal progressive condition, osteoarthritis is an
interesting target for research. It is estimated that the prevalence of knee osteoarthritis (OA) …
interesting target for research. It is estimated that the prevalence of knee osteoarthritis (OA) …
Cartilage homeostasis and osteoarthritis
Healthy limb joints are important for maintaining health and attaining longevity.
Endochondral ossification (the replacement of cartilage with bone, occurring during skeletal …
Endochondral ossification (the replacement of cartilage with bone, occurring during skeletal …
Nosology and classification of genetic skeletal disorders: 2019 revision
GR Mortier, DH Cohn, V Cormier‐Daire… - American journal of …, 2019 - Wiley Online Library
The application of massively parallel sequencing technology to the field of skeletal disorders
has boosted the discovery of the underlying genetic defect for many of these diseases. It has …
has boosted the discovery of the underlying genetic defect for many of these diseases. It has …
Integration of whole genome sequencing into a healthcare setting: high diagnostic rates across multiple clinical entities in 3219 rare disease patients
H Stranneheim, K Lagerstedt-Robinson… - Genome Medicine, 2021 - Springer
Background We report the findings from 4437 individuals (3219 patients and 1218 relatives)
who have been analyzed by whole genome sequencing (WGS) at the Genomic Medicine …
who have been analyzed by whole genome sequencing (WGS) at the Genomic Medicine …
Network regulation of microRNA biogenesis and target interaction
S Komatsu, H Kitai, HI Suzuki - Cells, 2023 - mdpi.com
MicroRNAs (miRNAs) are versatile, post-transcriptional regulators of gene expression.
Canonical miRNAs are generated through the two-step DROSHA-and DICER-mediated …
Canonical miRNAs are generated through the two-step DROSHA-and DICER-mediated …
Systems and synthetic microRNA biology: from biogenesis to disease pathogenesis
H Matsuyama, HI Suzuki - International journal of molecular sciences, 2019 - mdpi.com
MicroRNAs (miRNAs) are approximately 22-nucleotide-long, small non-coding RNAs that
post-transcriptionally regulate gene expression. The biogenesis of miRNAs involves multiple …
post-transcriptionally regulate gene expression. The biogenesis of miRNAs involves multiple …
The function of microRNAs in cartilage and osteoarthritis
T Swingler, L Niu, P Smith, P Paddy… - Clinical and …, 2019 - ueaeprints.uea.ac.uk
MicroRNAs are small double-stranded RNAs, which negatively regulate gene expression
and have been shown to have key roles in both chondrocyte development and cartilage …
and have been shown to have key roles in both chondrocyte development and cartilage …
Comprehensive analysis of human microRNA–mRNA interactome
MicroRNAs play a key role in the regulation of gene expression. A majority of microRNA–
mRNA interactions remain unidentified. Despite extensive research, our ability to predict …
mRNA interactions remain unidentified. Despite extensive research, our ability to predict …
Interplay between genetics and epigenetics in osteoarthritis
Research into the molecular genetics of osteoarthritis (OA) has been substantially bolstered
in the past few years by the implementation of powerful genome-wide scans that have …
in the past few years by the implementation of powerful genome-wide scans that have …
miR-149-3p regulates the switch between adipogenic and osteogenic differentiation of BMSCs by targeting FTO
Bone marrow-derived mesenchymal stem cells (BMSCs) have been suggested to possess
the capacity to differentiate into different cell lineages. Maintaining a balanced stem cell …
the capacity to differentiate into different cell lineages. Maintaining a balanced stem cell …