An area that has come to be of tremendous interest in tumor research in the last decade is
the role of the microenvironment in the biology of neoplastic diseases. The tumor …

Cell therapies offer a tailorable, personalized treatment for use in tissue engineering to
address defects arising from trauma, inefficient wound repair, or congenital malformation …

Background Innate immune cells such as macrophages are abundantly present within
malignant ascites, where they share the microenvironment with ovarian cancer stem cells …

Abstract Three-dimensional (3D) cell culture has tremendous advantages to closely mimic
the in vivo architecture and microenvironment of healthy tissue and organs, as well as of …

Abstract Three-dimensional (3D) culture systems are becoming increasingly popular due to
their ability to mimic tissue-like structures more effectively than the monolayer cultures. In …

Introduction: Cell-based assays using three-dimensional (3D) cell cultures may reflect the
antitumor activity of compounds more accurately, since these models reproduce the tumor …

BACKGROUND Epidemiologic studies suggest that metformin has antitumor effects.
Laboratory studies indicate metformin impacts cancer stem-like cells (CSCs). As part of a …

Abstract 3D in vitro model systems such as spheroids and organoids provide an opportunity
to extend the physiological understanding using recapitulated tissues that mimic …

Multicellular tumor spheroids are powerful in vitro models to perform preclinical
chemosensitivity assays. We compare different methodologies to generate tumor spheroids …

Ovarian cancer has the highest mortality of all of the gynecological malignancies. There are
several distinct histotypes of this malignancy characterized by specific molecular events and …