Donor-specific antibodies in kidney transplant recipients

R Zhang - Clinical Journal of the American Society of Nephrology, 2018 - journals.lww.com
Donor-specific antibodies have become an established biomarker predicting antibody-
mediated rejection. Antibody-mediated rejection is the leading cause of graft loss after …

[HTML][HTML] Developments in lung transplantation over the past decade

SC van der Mark, RAS Hoek… - European Respiratory …, 2020 - Eur Respiratory Soc
With an improved median survival of 6.2 years, lung transplantation has become an
increasingly acceptable treatment option for end-stage lung disease. Besides survival …

Cell-free DNA and active rejection in kidney allografts

RD Bloom, JS Bromberg, ED Poggio… - Journal of the …, 2017 - journals.lww.com
Histologic analysis of the allograft biopsy specimen is the standard method used to
differentiate rejection from other injury in kidney transplants. Donor-derived cell-free DNA …

Generation of hypoimmunogenic human pluripotent stem cells

X Han, M Wang, S Duan, PJ Franco… - Proceedings of the …, 2019 - National Acad Sciences
Polymorphic HLAs form the primary immune barrier to cell therapy. In addition, innate
immune surveillance impacts cell engraftment, yet a strategy to control both, adaptive and …

[HTML][HTML] Assessment of tocilizumab (anti–interleukin-6 receptor monoclonal) as a potential treatment for chronic antibody-mediated rejection and transplant …

J Choi, O Aubert, A Vo, A Loupy, M Haas… - American Journal of …, 2017 - Elsevier
Extending the functional integrity of renal allografts is the primary goal of transplant
medicine. The development of donor-specific antibodies (DSAs) posttransplantation leads to …

[HTML][HTML] 2016 comprehensive update of the Banff working group on liver allograft pathology: introduction of antibody-mediated rejection

AJ Demetris, C Bellamy, SG Hübscher, J O'leary… - American Journal of …, 2016 - Elsevier
The Banff Working Group on Liver Allograft Pathology reviewed and discussed literature
evidence regarding antibody-mediated liver allograft rejection at the 11th (Paris, France …

[HTML][HTML] HLA-DR/DQ molecular mismatch: a prognostic biomarker for primary alloimmunity

C Wiebe, V Kosmoliaptsis, D Pochinco… - American journal of …, 2019 - Elsevier
Alloimmune risk stratification in renal transplantation has lacked the necessary prognostic
biomarkers to personalize recipient care or optimize clinical trials. HLA molecular mismatch …

Detection of C3d-binding donor-specific anti-HLA antibodies at diagnosis of humoral rejection predicts renal graft loss

A Sicard, S Ducreux, M Rabeyrin, L Couzi… - Journal of the …, 2015 - journals.lww.com
Antibody-mediated rejection (AMR) is a major cause of kidney graft loss, yet assessment of
individual risk at diagnosis is impeded by the lack of a reliable prognosis assay. Here, we …

Chronic inflammatory placental disorders associated with recurrent adverse pregnancy outcome

EF Cornish, T McDonnell, DJ Williams - Frontiers in Immunology, 2022 - frontiersin.org
Chronic inflammatory placental disorders are a group of rare but devastating gestational
syndromes associated with adverse pregnancy outcome. This review focuses on three …

The treatment of antibody-mediated rejection in kidney transplantation: an updated systematic review and meta-analysis

SS Wan, TD Ying, K Wyburn, DM Roberts, M Wyld… - …, 2018 - journals.lww.com
Background Current treatments for antibody-mediated rejection (AMR) in kidney
transplantation are based on low-quality data from a small number of controlled trials. Novel …