Stem cell therapy combined with controlled release of growth factors for the treatment of sphincter dysfunction

S Shan, Q Li, T Criswell, A Atala, Y Zhang - Cell & Bioscience, 2023 - Springer
Sphincter dysfunction often occurs at the end of tubule organs such as the urethra, anus, or
gastroesophageal sphincters. It is the primary consequence of neuromuscular impairment …

Polyethylene glycol: the future of posttraumatic nerve repair? Systemic review

AM Paskal, W Paskal, P Pietruski… - International journal of …, 2019 - mdpi.com
Peripheral nerve injury is a common posttraumatic complication. The precise surgical repair
of nerve lesion does not always guarantee satisfactory motor and sensory function recovery …

Polyethylene glycol (PEG) and other bioactive solutions with neurorrhaphy for rapid and dramatic repair of peripheral nerve lesions by PEG-fusion

CL Ghergherehchi, M Mikesh, DR Sengelaub… - Journal of neuroscience …, 2019 - Elsevier
Background Nervous system injuries in mammals often involve transection or segmental
loss of peripheral nerves. Such injuries result in functional (behavioral) deficits poorly …

Polyethylene glycol solutions rapidly restore and maintain axonal continuity, neuromuscular structures, and behaviors lost after sciatic nerve transections in female …

M Mikesh, CL Ghergherehchi… - Journal of …, 2018 - Wiley Online Library
Complete severance of major peripheral mixed sensory–motor nerve proximally in a
mammalian limb produces immediate loss of action potential conduction and voluntary …

Long non-coding RNA NONMMUG014387 promotes Schwann cell proliferation after peripheral nerve injury

B Pan, Z Shi, J Yan, J Li, S Feng - Neural regeneration research, 2017 - journals.lww.com
Schwann cells play a critical role in peripheral nerve regeneration through dedifferentiation
and proliferation. In a previous study, we performed microarray analysis of the sciatic nerve …

Polyethylene glycol treated allografts not tissue matched nor immunosuppressed rapidly repair sciatic nerve gaps, maintain neuromuscular functions, and restore …

M Mikesh, CL Ghergherehchi, S Rahesh… - Journal of …, 2018 - Wiley Online Library
Many publications report that ablations of segments of peripheral nerves produce the
following unfortunate results:(1) Immediate loss of sensory signaling and motor control;(2) …

Down‐regulation of long non‐coding RNA MEG3 promotes Schwann cell proliferation and migration and repairs sciatic nerve injury in rats

Y Ma, D Zhai, W Zhang, H Zhang… - Journal of Cellular …, 2020 - Wiley Online Library
Peripheral nerve injury and regeneration are complex processes and involve multiple
molecular and signalling components. However, the involvement of long non‐coding RNA …

Evaluation of a nerve fusion technique with polyethylene glycol in a delayed setting after nerve injury

R Bamba, DC Riley, JS Kim, NL Cardwell… - The Journal of hand …, 2018 - Elsevier
Purpose Polyethylene glycol (PEG) has been hypothesized to restore axonal continuity
using an in vivo rat sciatic nerve injury model when nerve repair occurs within minutes after …

Functional and anatomical outcomes of facial nerve injury with application of polyethylene glycol in a rat model

BL Brown, T Asante, HR Welch… - JAMA facial plastic …, 2019 - jamanetwork.com
Importance Functional and anatomical outcomes after surgical repair of facial nerve injury
may be improved with the addition of polyethylene glycol (PEG) to direct suture …

Methylene blue enhances polyethylene glycol-fusion repair of completely severed rat sciatic nerves

CL Ghergherehchi, JT Shores, J Alderete… - Neural Regeneration …, 2021 - journals.lww.com
Complete transection of peripheral mixed nerves immediately produces loss of sensory
perception, muscle contractions and voluntary behavior mediated by the severed distal …