The completion of the Human Genome Project lays a foundation for systematically studying
the human genome from evolutionary history to precision medicine against diseases. With …

Mass spectrometry-based phosphoproteomics is becoming an essential methodology for the
study of global cellular signaling. Numerous bioinformatics resources are available to …

Protein phosphatases are the essential opposite to protein kinases; together, these enzymes
regulate all protein phosphorylation and most cellular processes. To better understand the …

Posttranslational modifications (PTM s) of proteins greatly expand proteome diversity,
increase functionality, and allow for rapid responses, all at relatively low costs for the cell …

Abstract The 19th annual Database Issue of Nucleic Acids Research features descriptions of
92 new online databases covering various areas of molecular biology and 100 papers …

Protein (de) phosphorylation plays an important role in plants. To provide a robust
foundation for subcellular phosphorylation signaling network analysis and kinase-substrate …

Background Protein kinases constitute a particularly large protein family in Arabidopsis with
important functions in cellular signal transduction networks. At the same time Arabidopsis is …

In this work, we developed a database WERAM (http://weram. biocuckoo. org/) for histone
acetyltransferases, histone deacetylases, histone methyltransferases, histone demethylases …

Post-translational modifications (PTMs) endow proteins with new properties to respond to
environmental changes or growth needs. With the development of advanced proteomics …

Phosphatases play key roles in normal physiology and diseases. Studying phosphatases
has been both essential and challenging, and the application of conventional genetic and …