Neural tube closure has been studied for many decades, across a range of vertebrates, as a
paradigm of embryonic morphogenesis. Neurulation is of particular interest in view of the …

BACKGROUND: The number of mouse mutants and strains with neural tube closure defects
(NTDs) now exceeds 190, including 155 involving known genes, 33 with unidentified genes …

Evidence from model organisms and clinical genetics suggests coordination between the
developing brain and face, but the role of this link in common genetic variation remains …

A dialogue between the hippocampus and the neocortex is thought to underlie the
formation, consolidation and retrieval of episodic memories,,,, although the nature of this …

Background Rhabdoid brain tumours, also called atypical teratoid rhabdoid tumours, are
lethal childhood cancers with characteristic genetic alterations of SMARCB1/hSNF5. Lack of …

The developmental process of neurulation involves a series of coordinated morphological
events, which result in conversion of the flat neural plate into the neural tube, the primordium …

Holoprosencephaly (HPE) has captivated the imagination of Man for millennia because its
most extreme manifestation, the single‐eyed cyclopic newborn infant, brings to mind the …

Background Childhood CNS primitive neuro-ectodermal brain tumours (PNETs) are very
aggressive brain tumours for which the molecular features and best treatment approaches …

The neural crest, a source of many different cell types in vertebrate embryos, has not been
identified in other chordates,,. Current opinion therefore holds that neural crest cells were a …

Spina bifida is among the phenotypes of the larger condition known as neural tube defects
(NTDs). It is the most common central nervous system malformation compatible with life and …