All metazoans depend on the consumption of O2 by the mitochondrial oxidative
phosphorylation system (OXPHOS) to produce energy. In addition, the OXPHOS uses O2 to …

RNase T1 is the best known representative of a large family of ribonucleolytic proteins
secreted by fungi, mostly Aspergillus and Penicillium species. Ribotoxins stand out among …

Ageritin is a specific ribonuclease, extracted from the edible mushroom Cyclocybe aegerita
(synonym Agrocybe aegerita), which cleaves a single phosphodiester bond located within …

Immunotoxins (ITXs) are chimeric molecules that combine the specificity of a targeting
domain, usually derived from an antibody, and the cytotoxic potency of a toxin, leading to the …

Fungi produce several toxins active against plants, animal or humans. Among them,
ribotoxins are enzymes that specifically attack ribosomes irreparably compromising protein …

Actinoporins are water-soluble proteins with the ability to form pores upon insertion into
biological membranes. They constitute a family of proteins with high degree of sequence …

Ribotoxins are potent inhibitors of protein biosynthesis and inactivate ribosomes from a
variety of organisms. The ribotoxin α-sarcin cleaves the large 23S ribosomal RNA (rRNA) at …

A single-chain fusion protein that directed the cytolytic activity of α-sarcin to A33 tumor
antigen expressing cells was constructed and shown to effectively kill targeted cells …

Simple Summary Antitumor therapy with immunotoxins is limited by problems of
immunogenicity and low efficacy in solid tumors. The different strategies to solve these …

Ribotoxins are a family of highly specific fungal ribonucleases that inactivate the ribosomes
by hydrolysis of a single phosphodiester bond of the 28 S rRNA. α-Sarcin, the best …