Recent advances in miRNA delivery systems

I Dasgupta, A Chatterjee - Methods and protocols, 2021 - mdpi.com
MicroRNAs (miRNAs) represent a family of short non-coding regulatory RNA molecules that
are produced in a tissue and time-specific manner to orchestrate gene expression post …

Advances in biosensing: The CRISPR/Cas system as a new powerful tool for the detection of nucleic acids

A Bonini, N Poma, F Vivaldi, A Kirchhain… - … of pharmaceutical and …, 2021 - Elsevier
A main challenge in the development of biosensing devices for the identification and
quantification of nucleic acids is to avoid the amplification of the genetic material from the …

MicroRNA dysregulations in Merkel cell carcinoma: Molecular mechanisms and clinical applications

C Mazziotta, CF Cervellera, C Lanzillotti… - Journal of Medical …, 2023 - Wiley Online Library
Merkel cell carcinoma (MCC) is an aggressive skin malignancy with two distinct etiologies.
The first, which accounts for the highest proportion, is caused by Merkel cell polyomavirus …

Emerging landscape of cell-penetrating peptide-mediated nucleic acid delivery and their utility in imaging, gene-editing, and RNA-sequencing

J Geng, X Xia, L Teng, L Wang, L Chen, X Guo… - Journal of Controlled …, 2022 - Elsevier
The safety issues like immunogenicity and unacceptable cancer risk of viral vectors for
DNA/mRNA vaccine delivery necessitate the development of non-viral vectors with no …

MicroRNAs modulate signaling pathways in osteogenic differentiation of mesenchymal stem cells

C Mazziotta, C Lanzillotti, MR Iaquinta… - International Journal of …, 2021 - mdpi.com
Mesenchymal stem cells (MSCs) have been identified in many adult tissues and they have
been closely studied in recent years, especially in view of their potential use for treating …

Bone regeneration and oxidative stress: an updated overview

AE Bădilă, DM Rădulescu, A Ilie, AG Niculescu… - Antioxidants, 2022 - mdpi.com
Bone tissue engineering is a complex domain that requires further investigation and benefits
from data obtained over past decades. The models are increasing in complexity as they …

microRNAs in the Regulation of Melanogenesis

Y Hushcha, I Blo, L Oton-Gonzalez, GD Mauro… - International Journal of …, 2021 - mdpi.com
Melanogenesis is the process leading to the synthesis of melanin, the main substance that
influences skin color and plays a pivotal role against UV damage. Altered melanogenesis is …

Targeted delivery system using silica nanoparticles coated with chitosan and AS1411 for combination therapy of doxorubicin and antimiR-21

F Khatami, MM Matin, NM Danesh, AR Bahrami… - Carbohydrate …, 2021 - Elsevier
Herein, a novel targeted delivery system was developed for intracellular co-delivery of
doxorubicin (DOX) as a chemotherapeutic drug, antimiR-21 as an oncogenic antagomiR. In …

Emergence of small interfering RNA-based gene drugs for various diseases

H Kurakula, S Vaishnavi, MY Sharif, S Ellipilli - ACS omega, 2023 - ACS Publications
Small molecule, peptide, and protein-based drugs have been developed over decades to
treat various diseases. The importance of gene therapy as an alternative to traditional drugs …

[HTML][HTML] LncRNA HOTAIR promotes the proliferation and invasion/metastasis of breast cancer cells by targeting the miR-130a-3p/Suv39H1 axis

W He, D Li, X Zhang - Biochemistry and Biophysics Reports, 2022 - Elsevier
Long noncoding RNAs (lncRNAs) are a group of transcripts, more than 200 bp in size and
regulate cell proliferation, differentiation and apoptosis. LncRNA HOX Transcript Antisense …