The hexosamine biosynthesis pathway: regulation and function

A Paneque, H Fortus, J Zheng, G Werlen, E Jacinto - Genes, 2023 - mdpi.com
The hexosamine biosynthesis pathway (HBP) produces uridine diphosphate-N-acetyl
glucosamine, UDP-GlcNAc, which is a key metabolite that is used for N-or O-linked …

Sporothrix schenckii complex and sporotrichosis, an emerging health problem

E López-Romero, MR Reyes-Montes… - Future …, 2011 - Taylor & Francis
Sporothrix schenckii, now named the S. schenckii species complex, has largely been known
as the etiological agent of sporotrichosis, which is an acute or chronic subcutaneous …

The role and its transcriptome mechanisms of cell wall polysaccharides in vanadium detoxication of rice

Y Yuan, M Imtiaz, M Rizwan, Z Dai, MM Hossain… - Journal of Hazardous …, 2022 - Elsevier
Cell wall-polysaccharides play a crucial role in heavy metals binding, and hence, contribute
to heavy metal detoxication in plants. However, there is no data regarding the molecular …

GFPT2/GFAT2 and AMDHD2 act in tandem to control the hexosamine pathway

V Kroef, S Ruegenberg, M Horn, K Allmeroth, L Ebert… - Elife, 2022 - elifesciences.org
The hexosamine biosynthetic pathway (HBP) produces the essential metabolite UDP-
GlcNAc and plays a key role in metabolism, health, and aging. The HBP is controlled by its …

Loss of GFAT-1 feedback regulation activates the hexosamine pathway that modulates protein homeostasis

S Ruegenberg, M Horn, C Pichlo, K Allmeroth… - Nature …, 2020 - nature.com
Abstract Glutamine fructose-6-phosphate amidotransferase (GFAT) is the key enzyme in the
hexosamine pathway (HP) that produces uridine 5′-diphospho-N-acetyl-d-glucosamine …

Highlights of glucosamine-6P synthase catalysis

P Durand, B Golinelli-Pimpaneau, S Mouilleron… - Archives of biochemistry …, 2008 - Elsevier
l-Glutamine: d-fructose-6-phosphate amidotransferase, also known as glucosamine-6-
phosphate synthase (GlcN6P synthase), which catalyzes the first step in a pathway leading …

Isocyanides inhibit bacterial pathogens by covalent targeting of essential metabolic enzymes

A Geißler, H Junca, AM Kany, LJ Daumann… - Chemical …, 2024 - pubs.rsc.org
Isonitrile natural products, also known as isocyanides, demonstrate potent antimicrobial
activities, yet our understanding of their molecular targets remains limited. Here, we focus on …

Protein kinase A controls the hexosamine pathway by tuning the feedback inhibition of GFAT-1

S Ruegenberg, FAMC Mayr, I Atanassov… - Nature …, 2021 - nature.com
The hexosamine pathway (HP) is a key anabolic pathway whose product uridine 5'-
diphospho-N-acetyl-D-glucosamine (UDP-GlcNAc) is an essential precursor for …

Valency engineering of monomeric enzymes for self-assembling biocatalytic hydrogels

P Bitterwolf, S Gallus, T Peschke, E Mittmann… - Chemical …, 2019 - pubs.rsc.org
All-enzyme hydrogels are efficient reagents for continuous flow biocatalysis. These materials
can be obtained by self-assembly of two oligomeric enzymes, modified with the …

Enzymatic and structural properties of human glutamine: fructose-6-phosphate amidotransferase 2 (hGFAT2)

IA Oliveira, D Allonso, TVA Fernandes… - Journal of Biological …, 2021 - ASBMB
Glycoconjugates play a central role in several cellular processes, and alteration in their
composition is associated with numerous human pathologies. Substrates for cellular …