Azole antifungal compounds could have dual cholinesterase inhibitory potential according to virtual screening, enzyme kinetics, and toxicity studies of an inhouse …

B Barut, S Sari, S Sabuncuoğlu, A Özel - Journal of Molecular Structure, 2021 - Elsevier
Recent advances in cholinesterase inhibitors opened new venues for the treatment of
cognitive disorders like Alzheimer's disease. Certain azole antifungals like miconazole were …

Azole derivatives with naphthalene showing potent antifungal effects against planktonic and biofilm forms of Candida spp.: an in vitro and in silico study

S Sari, E Koçak, D Kart, Z Özdemir, MF Acar… - International …, 2021 - Springer
Candida infections pose a serious public health threat due to increasing drug resistance.
Azoles are first-line antifungal drugs for fungal infections. In this study, we tested an in-house …

Antibacterial azole derivatives: Antibacterial activity, cytotoxicity, and in silico mechanistic studies

S Sari, A Avci, E Koçak, D Kart… - Drug Development …, 2020 - Wiley Online Library
Azole antifungal drugs are commonly used in antifungal chemotherapy. Antibacterial effects
of some topical antifungals, such as miconazole and econazole, have lately been revealed …

Discovery of potent α‐glucosidase inhibitors through structure‐based virtual screening of an in‐house azole collection

S Sari, B Barut, A Özel, S Saraç - Chemical Biology & Drug …, 2021 - Wiley Online Library
Diabetes mellitus, a chronic disorder characterized by hyperglycemia, is considered a
pandemic of modern times. α‐Glucosidase inhibitors emerged as a promising class of …

Design, Synthesis, and Molecular Modeling of New and Safe Azole Oxime Esters with Promising Antifungal Activity

S Yurtoğlu, S Sari, D Kart, S Sabuncuoğlu… - …, 2023 - Wiley Online Library
Fungal infections have become a major public health issue with dramatically increasing
morbidity, mortality and cost of hospitalization. Azole antifungals are first‐in‐line medications …

New Ester‐Containing Azole Derivatives With Potent Anti‐Candida Effects: Synthesis, Antifungal Susceptibility, Cytotoxicity, and Molecular Modeling Studies

Y Ataker, Ö Öncü, D Gülmez… - Drug Development …, 2024 - Wiley Online Library
Mortalities due to mycoses have dramatically increased with the emergence of drug‐
resistant strains and growing immune‐compromised populations globally. Azole antifungals …

Design, synthesis, antifungal activity, and QM/MM docking study of two azole derivatives with indole ring

S Sari, D Kart - Journal of Research in Pharmacy, 2020 - avesis.hacettepe.edu.tr
Systemic candidiasis is a major health issue for immunocompromised individuals due to the
increase in drug-resistance among Candida spp., which are prevalent pathogenic fungi …

Smart Agriculture: Integrating Sensor Networks and Microfluidics for Targeted Detection of Plant Pathogens

V Rodriguez, D Rakoto - Journal of Sustainable …, 2023 - publications.dlpress.org
Precision agriculture aims to optimize crop production and minimize environmental impact
by using technologies like sensors, robotics, and data analytics. An emerging area is the …

Advancements in Sensor Technologies for Microfluidic Systems: Implications for Drug Discovery and Plant Pathogen Detection

ML Chen, JH Wang - Journal of Empirical Social Science …, 2023 - publications.dlpress.org
Microfluidic systems integrated with sensors have shown great promise for applications in
drug discovery and plant pathogen detection. Recent advancements in sensor technologies …

Microfluidics in Drug Development: Enhancing Screening Accuracy with Advanced Sensor Integration

A Abdullah, M Rahman - International Journal of Responsible …, 2023 - neuralslate.com
Microfluidic technologies have revolutionized biological and chemical analysis by enabling
rapid, high-throughput screening in miniaturized formats. Microfluidic systems provide …