The confluence of recent discoveries of the roles of biomolecular liquids in living systems
and modern abilities to precisely synthesize and modify nucleic acids (NAs) has led to a …

The relationship between genotype and phenotype, or the fitness landscape, is the
foundation of genetic engineering and evolution. However, mapping fitness landscapes …

Conspectus Coacervates are droplets formed by liquid–liquid phase separation (LLPS) and
are often used as model protocells–primitive cell-like compartments that could have aided …

One of science's greatest challenges is determining how life can spontaneously emerge
from a mixture of molecules. A complicating factor is that life and its molecules are inherently …

Conspectus Creating a living system from nonliving matter is a great challenge in chemistry
and biophysics. The early history of life can provide inspiration from the idea of the prebiotic …

The origin of life, being one of the most fascinating questions in science, is increasingly
addressed by interdisciplinary research. In addition to developing plausible chemical …

At the earliest development of prebiotic chemistry, bacterial cells were primarily viewed as
“bags of molecules.” This longstanding viewpoint shaped and biased early research about …

The RNA world hypothesis confers a central role to RNA molecules in information encoding
and catalysis. Even though evidence in support of this hypothesis has accumulated from …

Phase-separated compartments can localize (bio) chemical reactions and influence their
kinetics. They are believed to play an important role both in extant life in the form of …

Abstract (EN) Compartmentalisation and metabolism are two universal features observed
among all living organisms. Their emergence and harmonious functioning are considered …