Fusion of enveloped viruses in endosomes
JM White, GR Whittaker - Traffic, 2016 - Wiley Online Library
Ari Helenius launched the field of enveloped virus fusion in endosomes with a seminal
paper in the Journal of Cell Biology in 1980. In the intervening years, a great deal has been …
paper in the Journal of Cell Biology in 1980. In the intervening years, a great deal has been …
Influenza virus-mediated membrane fusion: determinants of hemagglutinin fusogenic activity and experimental approaches for assessing virus fusion
BS Hamilton, GR Whittaker, S Daniel - Viruses, 2012 - mdpi.com
Hemagglutinin (HA) is the viral protein that facilitates the entry of influenza viruses into host
cells. This protein controls two critical aspects of entry: virus binding and membrane fusion …
cells. This protein controls two critical aspects of entry: virus binding and membrane fusion …
Stepwise Priming by Acidic pH and a High K+ Concentration Is Required for Efficient Uncoating of Influenza A Virus Cores after Penetration
Influenza A virus (IAV) uses the low pH in late endocytic vacuoles as a cue for penetration by
membrane fusion. Here, we analyzed the prefusion reactions that prepare the core for …
membrane fusion. Here, we analyzed the prefusion reactions that prepare the core for …
Influenza-virus membrane fusion by cooperative fold-back of stochastically induced hemagglutinin intermediates
Influenza virus penetrates cells by fusion of viral and endosomal membranes catalyzed by
the viral hemagglutinin (HA). Structures of the initial and final states of the HA trimer define …
the viral hemagglutinin (HA). Structures of the initial and final states of the HA trimer define …
Atomic structures of closed and open influenza B M2 proton channel reveal the conduction mechanism
VS Mandala, AR Loftis, AA Shcherbakov… - Nature structural & …, 2020 - nature.com
Abstract The influenza B M2 (BM2) proton channel is activated by acidic pH to mediate virus
uncoating. Unlike influenza A M2 (AM2), which conducts protons with strong inward …
uncoating. Unlike influenza A M2 (AM2), which conducts protons with strong inward …
Low-fidelity assembly of influenza A virus promotes escape from host cells
MD Vahey, DA Fletcher - Cell, 2019 - cell.com
Influenza viruses inhabit a wide range of host environments using a limited repertoire of
protein components. Unlike viruses with stereotyped shapes, influenza produces virions with …
protein components. Unlike viruses with stereotyped shapes, influenza produces virions with …
Sequential conformational rearrangements in flavivirus membrane fusion
The West Nile Virus (WNV) envelope protein, E, promotes membrane fusion during viral cell
entry by undergoing a low-pH triggered conformational reorganization. We have examined …
entry by undergoing a low-pH triggered conformational reorganization. We have examined …
Identification of traditional medicinal plant extracts with novel anti-influenza activity
D Rajasekaran, EA Palombo, T Chia Yeo… - PloS one, 2013 - journals.plos.org
The emergence of drug resistant variants of the influenza virus has led to a need to identify
novel and effective antiviral agents. As an alternative to synthetic drugs, the consolidation of …
novel and effective antiviral agents. As an alternative to synthetic drugs, the consolidation of …
Single particle assay of coronavirus membrane fusion with proteinaceous receptor-embedded supported bilayers
Total internal reflection microscopy combined with microfluidics and supported bilayers is a
powerful, single particle tracking (SPT) platform for host-pathogen membrane fusion studies …
powerful, single particle tracking (SPT) platform for host-pathogen membrane fusion studies …
The shape of pleomorphic virions determines resistance to cell-entry pressure
Many enveloped animal viruses produce a variety of particle shapes, ranging from small
spherical to long filamentous types. Characterization of how the shape of the virion affects …
spherical to long filamentous types. Characterization of how the shape of the virion affects …