The NLRP3 inflammasome is a critical component of the innate immune system that
mediates caspase-1 activation and the secretion of proinflammatory cytokines IL-1β/IL-18 in …

The NLRP3 inflammasome is a multimeric protein complex that initiates an inflammatory
form of cell death and triggers the release of proinflammatory cytokines IL-1β and IL-18. The …

Inflammasomes are multi-protein signaling complexes that trigger the activation of
inflammatory caspases and the maturation of interleukin-1β. Among various inflammasome …

Infection is a dynamic biological process underpinned by a complex interplay between the
pathogen and the host. Microbes from all domains of life, including bacteria, viruses, fungi …

Group B Streptococcus (GBS) colonizes the gastrointestinal and vaginal epithelium of a
significant percentage of healthy women, with potential for ascending intrauterine infection …

Neurological diseases, including acute attacks (eg, ischemic stroke) and chronic
neurodegenerative diseases (eg, Alzheimer's disease), have always been one of the …

Host recognition of microbial components is essential in mediating an effective immune
response. Cytosolic bacteria must secure entry into the host cytoplasm to facilitate …

Inflammasome activation is associated with numerous diseases. However, in vivo detection
of the activated inflammasome complex has been limited by a dearth of tools. We have …

Streptococcus agalactiae (Group B streptococcus, GBS) is highly adapted to humans, where
it is a normal constituent of the intestinal and vaginal flora. Yet, GBS has highly invasive …

The inflammasomes are intracellular protein complexes that play an important role in innate
immune sensing. Activation of inflammasomes leads to activation of caspase-1 and …