Deep insight of the pathophysiology of gestational diabetes mellitus

AK Sharma, S Singh, H Singh, D Mahajan, P Kolli… - Cells, 2022 - mdpi.com
Diabetes mellitus is a severe metabolic disorder, which consistently requires medical care
and self-management to restrict complications, such as obesity, kidney damage and …

Role of extracellular vesicles and microRNAs on dysfunctional angiogenesis during preeclamptic pregnancies

CA Escudero, K Herlitz, F Troncoso, J Acurio… - Frontiers in …, 2016 - frontiersin.org
Preeclampsia is a syndrome characterized by hypertension during pregnancy, which is a
leading cause of morbidity and mortality in both mother and newborn in developing …

Preeclampsia and cardiovascular disease death: prospective evidence from the child health and development studies cohort

ML Mongraw-Chaffin, PM Cirillo, BA Cohn - Hypertension, 2010 - Am Heart Assoc
This study prospectively investigates the contribution of pregnancy complications and other
reproductive age risk factors on the risk of subsequent cardiovascular disease death …

[HTML][HTML] The influence of the dietary exposome on oxidative stress in pregnancy complications

JR Prins, MH Schoots, JI Wessels… - Molecular Aspects of …, 2022 - Elsevier
Pregnancy complications including fetal growth restriction, preeclampsia, and preterm birth,
as well as gestational diabetes, affect one in every four to five pregnancies. Accumulating …

Differential placental macrovascular and microvascular endothelial dysfunction in gestational diabetes

L Sobrevia, F Abarzúa, JK Nien, C Salomón… - Placenta, 2011 - Elsevier
Human endothelial dysfunction is a common feature in many diseases of pregnancy, such
as gestational diabetes (GD). Metabolic changes include abnormal synthesis of nitric oxide …

[HTML][HTML] Inhibition of HIF-1a-mediated TLR4 activation decreases apoptosis and promotes angiogenesis of placental microvascular endothelial cells during severe pre …

L Zhao, R Ma, L Zhang, X Yuan, J Wu, L He, G Liu… - Placenta, 2019 - Elsevier
Objective Hypoxia-induced factor 1a (HIF-1a) and Toll-like receptor 4 (TLR4) are involved in
pre-eclampsia (PE) pathogenesis. However, little is known about their relationships. This …

Adenosine A2a receptors and O2 sensing in development

BJ Koos - … Journal of Physiology-Regulatory, Integrative and …, 2011 - journals.physiology.org
Reduced mitochondrial oxidative phosphorylation, via activation of adenylate kinase and the
resulting exponential rise in the cellular AMP/ATP ratio, appears to be a critical factor …

Endothelial dysfunction in the pathogenesis of pre-eclampsia in Ghanaian women

K Adu-Bonsaffoh, DA Antwi, B Gyan, SA Obed - BMC physiology, 2017 - Springer
Background Pre-eclampsia (PE) remains a disease of theories despite extensive research
into its etiology. Alteration in the production of vascular endothelial growth factor (VEGF), a …

Factores de riesgo asociados con preeclampsia severa (con criterios de severidad)

J Duarte, ME Ezeta, G Sánchez… - Medicina Interna de …, 2022 - medigraphic.com
La mortalidad materno-perinatal sigue siendo alta en todo el mundo. Los costos de atención
también se han incrementado de forma alarmante. Existen factores de riesgo bien …

Impaired adenosine-mediated angiogenesis in preeclampsia: potential implications for fetal programming

C Escudero, JM Roberts, L Myatt… - Frontiers in …, 2014 - frontiersin.org
Preeclampsia is a pregnancy-specific syndrome, defined by such clinical hallmarks as the
onset of maternal hypertension and proteinuria after 20 weeks of gestation. The syndrome is …