Biogenesis and regulatory roles of circular RNAs

L Yang, JE Wilusz, LL Chen - Annual review of cell and …, 2022 - annualreviews.org
Covalently closed, single-stranded circular RNAs can be produced from viral RNA genomes
as well as from the processing of cellular housekeeping noncoding RNAs and precursor …

CircRNAs in anticancer drug resistance: recent advances and future potential

T Xu, M Wang, L Jiang, L Ma, L Wan, Q Chen, C Wei… - Molecular cancer, 2020 - Springer
CircRNAs are a novel class of RNA molecules with a unique closed continuous loop
structure. CircRNAs are abundant in eukaryotic cells, have unique stability and tissue …

Emerging roles of circRNAs in the pathological process of myocardial infarction

ZJ Wen, H Xin, YC Wang, HW Liu, YY Gao… - … Therapy-Nucleic Acids, 2021 - cell.com
Myocardial infarction (MI) is defined as cardiomyocyte death in a clinical context consistent
with ischemic insult. MI remains one of the leading causes of morbidity and mortality …

The role and clinical potentials of circular RNAs in prostate cancer

M Taheri, S Najafi, A Basiri, BM Hussen… - Frontiers in …, 2021 - frontiersin.org
Globally, prostate cancer (PCa) is the second most commonly diagnosed cancer in men
globally. Early diagnosis may help in promoting survival in the affected patients. Circular …

Circular RNAs in the tumour microenvironment

Z Ma, Y Shuai, X Gao, X Wen, J Ji - Molecular Cancer, 2020 - Springer
Abstract Background Circular RNAs (circRNAs) are a new class of endogenous non-coding
RNAs (ncRNAs) widely expressed in eukaryotic cells. Mounting evidence has highlighted …

Challenges and opportunities for circRNA identification and delivery

J Dong, Z Zeng, Y Huang, C Chen… - Critical reviews in …, 2023 - Taylor & Francis
Circular RNAs (circRNAs) are evolutionarily conserved noncoding RNAs with tissue-specific
expression patterns, and exert unique cellular functions that have the potential to become …

circRNA-miRNA-mRNA deregulated network in ischemic heart failure patients

A Madè, A Bibi, JM Garcia-Manteiga, AS Tascini… - Cells, 2023 - mdpi.com
Noncoding RNAs (ncRNAs), which include circular RNAs (circRNAs) and microRNAs
(miRNAs), regulate the development of cardiovascular diseases (CVD). Notably, circRNAs …

Competing endogenous RNA network profiling reveals novel host dependency factors required for MERS-CoV propagation

X Zhang, H Chu, L Wen, H Shuai, D Yang… - Emerging microbes & …, 2020 - Taylor & Francis
Circular RNAs (circRNAs) are an integral component of the host competitive endogenous
RNA (ceRNA) network. These noncoding RNAs are characterized by their unique splicing …

Advanced technological tools to study multidrug resistance in cancer

L Andrei, S Kasas, IO Garrido, T Stanković… - Drug Resistance …, 2020 - Elsevier
The complexity of cancer biology and its clinical manifestation are driven by genetic,
epigenetic, transcriptomic, proteomic and metabolomic alterations, supported by genomic …

The implications of ncRNAs in the development of human diseases

E López-Jiménez, E Andrés-León - Non-coding RNA, 2021 - mdpi.com
The mammalian genome comprehends a small minority of genes that encode for proteins
(barely 2% of the total genome in humans) and an immense majority of genes that are …