Large conductance Ca 2+-and voltage-activated K+(BK) channels are widely distributed in
the postnatal central nervous system (CNS). BK channels play a pleiotropic role in …

Neuronal firing patterns and frequencies determine the nature of encoded information of the
neurons. Here we discuss the molecular identity and cellular mechanisms of spike …

Large conductance, Ca2+-activated K+ (BK) channels represent an important pathway for
the outward flux of K+ ions from the intracellular compartment in response to membrane …

The large-conductance voltage-and calcium-activated potassium (BK) channels are
ubiquitously expressed in the brain and play an important role in the regulation of neuronal …

BK calcium-activated potassium channels have complex kinetics because they are activated
by both voltage and cytoplasmic calcium. The timing of BK activation and deactivation during …

Cerebellar ataxia is a frequent and often disabling syndrome severely impairing motor
functioning and quality of life. Patients suffer from reduced mobility, and restricted autonomy …

Purkinje cells (PCs) are the principal cells of the cerebellar cortex and form a central
element in the modular organization of the cerebellum. Differentiation of PCs based on gene …

DYT1 dystonia is an inherited movement disorder caused by a heterozygous trinucleotide
(GAG) deletion in DYT1/TOR1A, coding for torsinA. Growing evidence suggests that the …

BK Ca-channel activity often affects the firing properties of neurons, the shapes of neuronal
action potentials (APs), and in some cases the extent of neurotransmitter release. It has …

Key points• Stress can lead to the development of behavioural disorders associated with
cognitive impairments, depression and anxiety.• Large‐conductance Ca2+‐activated …