The emerging role of mass spectrometry-based proteomics in drug discovery
Proteins are the main targets of most drugs; however, system-wide methods to monitor
protein activity and function are still underused in drug discovery. Novel biochemical …
protein activity and function are still underused in drug discovery. Novel biochemical …
High-resolution native mass spectrometry
Native mass spectrometry (MS) involves the analysis and characterization of
macromolecules, predominantly intact proteins and protein complexes, whereby as much as …
macromolecules, predominantly intact proteins and protein complexes, whereby as much as …
Profiling the human intestinal environment under physiological conditions
The spatiotemporal structure of the human microbiome,, proteome and metabolome, reflects
and determines regional intestinal physiology and may have implications for disease. Yet …
and determines regional intestinal physiology and may have implications for disease. Yet …
Ultra‐high sensitivity mass spectrometry quantifies single‐cell proteome changes upon perturbation
AD Brunner, M Thielert, C Vasilopoulou… - Molecular systems …, 2022 - embopress.org
Single‐cell technologies are revolutionizing biology but are today mainly limited to imaging
and deep sequencing. However, proteins are the main drivers of cellular function and in …
and deep sequencing. However, proteins are the main drivers of cellular function and in …
Proteomic profiling platforms head to head: leveraging genetics and clinical traits to compare aptamer-and antibody-based methods
High-throughput proteomic profiling using antibody or aptamer-based affinity reagents is
used increasingly in human studies. However, direct analyses to address the relative …
used increasingly in human studies. However, direct analyses to address the relative …
Ultra-high-throughput clinical proteomics reveals classifiers of COVID-19 infection
The COVID-19 pandemic is an unprecedented global challenge, and point-of-care
diagnostic classifiers are urgently required. Here, we present a platform for ultra-high …
diagnostic classifiers are urgently required. Here, we present a platform for ultra-high …
Genetics meets proteomics: perspectives for large population-based studies
Proteomic analysis of cells, tissues and body fluids has generated valuable insights into the
complex processes influencing human biology. Proteins represent intermediate phenotypes …
complex processes influencing human biology. Proteins represent intermediate phenotypes …
Advances and utility of the human plasma proteome
The study of proteins circulating in blood offers tremendous opportunities to diagnose,
stratify, or possibly prevent diseases. With recent technological advances and the urgent …
stratify, or possibly prevent diseases. With recent technological advances and the urgent …
Data‐independent acquisition‐based SWATH‐MS for quantitative proteomics: a tutorial
Many research questions in fields such as personalized medicine, drug screens or systems
biology depend on obtaining consistent and quantitatively accurate proteomics data from …
biology depend on obtaining consistent and quantitatively accurate proteomics data from …
Rapid, deep and precise profiling of the plasma proteome with multi-nanoparticle protein corona
JE Blume, WC Manning, G Troiano, D Hornburg… - Nature …, 2020 - nature.com
Large-scale, unbiased proteomics studies are constrained by the complexity of the plasma
proteome. Here we report a highly parallel protein quantitation platform integrating …
proteome. Here we report a highly parallel protein quantitation platform integrating …