The clinical utility of droplet digital PCR for profiling circulating tumor DNA in breast cancer patients

U Gezer, AJ Bronkhorst, S Holdenrieder - Diagnostics, 2022 - mdpi.com
Breast cancer is the most common cancer affecting women worldwide. It is a malignant and
heterogeneous disease with distinct molecular subtypes, which has prognostic and …

Cell free DNA as a diagnostic and prognostic marker for cardiovascular diseases

IA Polina, DV Ilatovskaya, KY DeLeon-Pennell - Clinica Chimica Acta, 2020 - Elsevier
Release of cell free DNA (cfDNA) from damaged or dead cells routinely occurs in normal
physiology. Recently, cfDNA has emerged as an essential biomarker in cardiovascular …

Efficacy of cell-free DNA as a diagnostic biomarker in breast cancer patients

I Khurram, MU Khan, S Ibrahim, A Saleem, Z Khan… - Scientific Reports, 2023 - nature.com
Breast cancer is the most prevalent and leading cause of mortality worldwide among
women. Cell-free DNA (cfDNA) analysis is an alternative quantitative approach to …

Critical review on where CRISPR meets molecular diagnostics

A Lau, C Ren, LP Lee - Progress in Biomedical Engineering, 2020 - iopscience.iop.org
Simple yet powerful clustered regularly-interspaced short palindromic repeats (CRISPR)
technology has led to the advent of numerous developments in life sciences, biotechnology …

Impact of preanalytical and analytical methods on cell-free DNA diagnostics

J Krasic, I Abramovic, A Vrtaric… - Frontiers in cell and …, 2021 - frontiersin.org
While tissue biopsy has for the longest time been the gold-standard in biomedicine,
precision/personalized medicine is making the shift toward liquid biopsies. Cell-free DNA …

Peripheral blood-based biopsy for breast cancer risk prediction and early detection

FJ Nassar, G Chamandi, MA Tfaily, NK Zgheib… - Frontiers in …, 2020 - frontiersin.org
Among women, breast cancer (BC) is not only the most common cancer worldwide but also
the leading cause of cancer death. Only 5–10% of breast cancer cases are attributed to …

The paradox of cancer genes in non-malignant conditions: implications for precision medicine

JJ Adashek, S Kato, SM Lippman, R Kurzrock - Genome medicine, 2020 - Springer
Next-generation sequencing has enabled patient selection for targeted drugs, some of
which have shown remarkable efficacy in cancers that have the cognate molecular …

Evaluation of automated techniques for extraction of circulating cell-free DNA for implementation in standardized high-throughput workflows

S Lehle, J Emons, CC Hack, F Heindl, A Hein… - Scientific Reports, 2023 - nature.com
Abstract Analysis of circulating cell-free DNA (ccfDNA) is a suitable tool for detecting somatic
mutations for the purpose of making decisions on treatment, monitoring treatment response …

Circulating cell-free DNA in breast cancer: Searching for hidden information towards precision medicine

M Panagopoulou, M Esteller, E Chatzaki - Cancers, 2021 - mdpi.com
Simple Summary Our research focuses in the elucidation of the nature of circulating cell-free
DNA (ccfDNA) as a biological entity and its exploitation as a liquid biopsy biomaterial …

The breast is yet to come: current and future utility of circulating tumour DNA in breast cancer

BA Davidson, S Croessmann, BH Park - British Journal of Cancer, 2021 - nature.com
Advances in genomic strategies and the development of targeted therapies have enabled
precision medicine to revolutionise the field of oncology. Precision medicine uses patient …