Mesenchymal stem/stromal cells as a valuable source for the treatment of immune-mediated disorders

A Markov, L Thangavelu, S Aravindhan… - Stem cell research & …, 2021 - Springer
Over recent years, mesenchymal stem/stromal cells (MSCs) and their potential biomedical
applications have received much attention from the global scientific community in an …

[HTML][HTML] Plant-derived exosome-like nanoparticles and their therapeutic activities

J Kim, S Li, S Zhang, J Wang - Asian journal of pharmaceutical sciences, 2022 - Elsevier
Nanotechnologies have been successfully applied to the treatment of various diseases.
Plant-derived exosome-like nanoparticles (PENs) are expected to become effective …

Linkage between endosomal escape of LNP-mRNA and loading into EVs for transport to other cells

M Maugeri, M Nawaz, A Papadimitriou… - Nature …, 2019 - nature.com
RNA-based therapeutics hold great promise for treating diseases and lipid nanoparticles
(LNPs) represent the most advanced platform for RNA delivery. However, the fate of the LNP …

Methodological guidelines to study extracellular vesicles

FAW Coumans, AR Brisson, EI Buzas… - Circulation …, 2017 - Am Heart Assoc
Owing to the relationship between extracellular vesicles (EVs) and physiological and
pathological conditions, the interest in EVs is exponentially growing. EVs hold high hopes …

Microfluidics for exosome isolation and analysis: enabling liquid biopsy for personalized medicine

JC Contreras-Naranjo, HJ Wu, VM Ugaz - Lab on a Chip, 2017 - pubs.rsc.org
Exosomes, the smallest sized extracellular vesicles (∽ 30–150 nm) packaged with lipids,
proteins, functional messenger RNAs and microRNAs, and double-stranded DNA from their …

Obstacles and opportunities in the functional analysis of extracellular vesicle RNA–an ISEV position paper

B Mateescu, EJK Kowal, BWM Van Balkom… - Journal of …, 2017 - Taylor & Francis
The release of RNA-containing extracellular vesicles (EV) into the extracellular milieu has
been demonstrated in a multitude of different in vitro cell systems and in a variety of body …

Technical challenges of working with extracellular vesicles

MI Ramirez, MG Amorim, C Gadelha, I Milic, JA Welsh… - Nanoscale, 2018 - pubs.rsc.org
Extracellular Vesicles (EVs) are gaining interest as central players in liquid biopsies, with
potential applications in diagnosis, prognosis and therapeutic guidance in most pathological …

Techniques used for the isolation and characterization of extracellular vesicles: results of a worldwide survey

C Gardiner, DD Vizio, S Sahoo, C Théry… - Journal of …, 2016 - Taylor & Francis
Extracellular vesicles (EVs) represent an important mode of intercellular communication.
Research in this field has grown rapidly in the last few years, and there is a plethora of …

Extracellular vesicle isolation and characterization: toward clinical application

R Xu, DW Greening, HJ Zhu… - The Journal of …, 2016 - Am Soc Clin Investig
Two broad categories of extracellular vesicles (EVs), exosomes and shed microvesicles
(sMVs), which differ in size distribution as well as protein and RNA profiles, have been …

Exosome biochemistry and advanced nanotechnology for next‐generation theranostic platforms

B Yang, Y Chen, J Shi - Advanced Materials, 2019 - Wiley Online Library
Recent marked technological advances in the field of exosome nanotechnology have
provided unprecedented opportunities to bloom the developments of exosome‐related …