The continuing increase in the prevalence of diabetes mellitus in the general population is
predicted to result in a higher incidence of cardiovascular disease. Although the …

Medial vascular calcification has emerged as a putative key factor contributing to the
excessive cardiovascular mortality of patients with chronic kidney disease (CKD) …

Objectives: Vascular calcification is highly prevalent in patients with chronic kidney disease.
Increased plasma trimethylamine N-oxide (TMAO), a gut microbiota-dependent product …

Arterial occlusive disease is the leading cause of death in Western countries. Core
contemporary therapies for this disease include angioplasties, stents, endarterectomies and …

Vascular calcification is highly prevalent in end-stage renal diseases and is predictive of
cardiovascular events and mortality. Poly (ADP-ribose) polymerase 1 (PARP1) inhibition or …

Medial vascular calcification, associated with enhanced mortality in chronic kidney disease
(CKD), is fostered by osteo-/chondrogenic transdifferentiation of vascular smooth muscle …

Autophagy is a dynamic and highly regulated process of self-digestion responsible for cell
survival and reaction to oxidative stress. As oxidative stress is increased in uremia and is …

Background The high cardiovascular morbidity and mortality of patients with CKD may result
in large part from medial vascular calcification, a process promoted by hyperphosphatemia …

It is today acknowledged that aging is associated with a low-grade chronic inflammatory
status, and that inflammation exacerbates age-related diseases such as osteoporosis …

Hyperphosphatemia contributes to increased cardiovascular mortality through vascular
calcification (VC) in patients with chronic kidney disease (CKD). Malnutrition and …