Mechanism of All-Trans Retinoic Acid Effect on Tumor-Associated Myeloid-Derived Suppressor Cells
Y Nefedova, M Fishman, S Sherman, X Wang, AA Beg… - Cancer research, 2007 - AACR
Myeloid-derived suppressor cells (MDSC) play an important role in tumor escape by
suppressing T-cell responses. MDSC represent a group of cells of myeloid lineage at …
suppressing T-cell responses. MDSC represent a group of cells of myeloid lineage at …
Emerging importance of phytochemicals in regulation of stem cells fate via signaling pathways
M Dadashpour, Y Pilehvar‐Soltanahmadi… - Phytotherapy …, 2017 - Wiley Online Library
To reach ideal therapeutic potential of stem cells for regenerative medicine purposes, it is
essential to retain their self‐renewal and differentiation capacities. Currently, biological …
essential to retain their self‐renewal and differentiation capacities. Currently, biological …
Vitamin D3-driven signals for myeloid cell differentiation—Implications for differentiation therapy
PJ Hughes, E Marcinkowska, E Gocek, GP Studzinski… - Leukemia research, 2010 - Elsevier
Primitive myeloid leukemic cell lines can be driven to differentiate to monocyte-like cells by
1α, 25-dihydroxyvitamin D3 (1, 25 (OH) 2D3), and, therefore, 1, 25 (OH) 2D3 may be useful …
1α, 25-dihydroxyvitamin D3 (1, 25 (OH) 2D3), and, therefore, 1, 25 (OH) 2D3 may be useful …
Retinoic acid activation of the ERK pathway is required for embryonic stem cell commitment into the adipocyte lineage
Mouse embryonic stem (ES) cells are pluripotent cells that differentiate into multiple cell
lineages. The commitment of ES cells into the adipocyte lineage is dependent on an early 3 …
lineages. The commitment of ES cells into the adipocyte lineage is dependent on an early 3 …
Importance of MEK-1/-2 signaling in monocytic and granulocytic differentiation of myeloid cell lines
Activation of the MEK/ERK/MAP kinase signaling pathway promotes the proliferation and
survival of hematopoietic cells. The kinases MEK-1, MEK-2, ERK-1/MAPK and ERK-2/MAPK …
survival of hematopoietic cells. The kinases MEK-1, MEK-2, ERK-1/MAPK and ERK-2/MAPK …
Nonclassical action of retinoic acid on the activation of the cAMP response element-binding protein in normal human bronchial epithelial cells
S Aggarwal, SW Kim, K Cheon… - Molecular biology of …, 2006 - Am Soc Cell Biol
Vitamin A (retinol) is essential for normal regulation of cell growth and differentiation. We
have shown that the retinol metabolite retinoic acid (RA) induces mucous cell differentiation …
have shown that the retinol metabolite retinoic acid (RA) induces mucous cell differentiation …
In vivo and in vitro roles of IL-21 in inflammation
M Pelletier, A Bouchard, D Girard - The Journal of Immunology, 2004 - journals.aai.org
IL-21 is a cytokine known to mediate its biological action via the IL-21R, composed of a
specific chain, IL-21Rα, and the common γ-chain (CD132). Recent data suggest that IL-21 …
specific chain, IL-21Rα, and the common γ-chain (CD132). Recent data suggest that IL-21 …
Activation of the Aryl hydrocarbon receptor ahr promotes retinoic acid–induced differentiation of myeloblastic leukemia cells by restricting expression of the stem cell …
RP Bunaciu, A Yen - Cancer research, 2011 - AACR
Retinoic acid (RA) is used to treat leukemia and other cancers through its ability to promote
cancer cell differentiation. Strategies to enhance the anticancer effects of RA could deepen …
cancer cell differentiation. Strategies to enhance the anticancer effects of RA could deepen …
Magnolol and honokiol enhance HL-60 human leukemia cell differentiation induced by 1, 25-dihydroxyvitamin D3 and retinoic acid
WF Fong, AKW Tse, KH Poon, C Wang - The International Journal of …, 2005 - Elsevier
Magnolol (MG) and honokiol (HK), two lignans showing anti-inflammatory and anti-oxidant
properties and abundantly available in the medicinal plants Magnolia officinalis and M …
properties and abundantly available in the medicinal plants Magnolia officinalis and M …
Inhibition of p38 MAP kinase activity up-regulates multiple MAP kinase pathways and potentiates 1, 25-dihydroxyvitamin D3-induced differentiation of human leukemia …
X Wang, J Rao, GP Studzinski - Experimental cell research, 2000 - Elsevier
Differentiation therapy for neoplastic diseases has potential for supplementing existing
treatment modalities but its implementation has been slow. One of the reasons is the lack of …
treatment modalities but its implementation has been slow. One of the reasons is the lack of …