Modulation of host immunity by helminths: the expanding repertoire of parasite effector molecules

RM Maizels, HH Smits, HJ McSorley - Immunity, 2018 - cell.com
Helminths are extraordinarily successful parasites due to their ability to modulate the host
immune response. They have evolved a spectrum of immunomodulatory molecules that are …

Soil-transmitted helminth infections: ascariasis, trichuriasis, and hookworm

J Bethony, S Brooker, M Albonico, SM Geiger… - The lancet, 2006 - thelancet.com
The three main soil-transmitted helminth infections, ascariasis, trichuriasis, and hookworm,
are common clinical disorders in man. The gastrointestinal tract of a child living in poverty in …

[HTML][HTML] Helminth immunoregulation: the role of parasite secreted proteins in modulating host immunity

JP Hewitson, JR Grainger, RM Maizels - Molecular and biochemical …, 2009 - Elsevier
Helminths are masterful immunoregulators. A characteristic feature of helminth infection is a
Th2-dominated immune response, but stimulation of immunoregulatory cell populations …

[PDF][PDF] Molecules released by helminth parasites involved in host colonization

J Dzik - Acta Biochimica Polonica, 2006 - bibliotekanauki.pl
Parasites are designed by evolution to invade the host and survive in its organism until they
are ready to reproduce. Parasites release a variety of molecules that help them to penetrate …

The immune response to nematode infection

M Stear, S Preston, D Piedrafita… - International Journal of …, 2023 - mdpi.com
Nematode infection is a major threat to the health of humans, domestic animals and wildlife.
Nematodes vary in their effect on the host and in the mechanisms underlying immunity but …

Trichinella spiralis: nurse cell formation with emphasis on analogy to muscle cell repair

Z Wu, L Sofronic-Milosavljevic, I Nagano… - Parasites & vectors, 2008 - Springer
Trichinella infection results in formation of a capsule in infected muscles. The capsule is a
residence of the parasite which is composed of the nurse cell and fibrous wall. The process …

Homologues of human macrophage migration inhibitory factor from a parasitic nematode: Gene cloning, protein activity, and crystal structure

X Zang, P Taylor, JM Wang, DJ Meyer, AL Scott… - Journal of Biological …, 2002 - ASBMB
Cytokines are the molecular messengers of the vertebrate immune system, coordinating the
local and systemic immune responses to infective organisms. We report here functional and …

Functional genes and proteins of Trichinella spp.

I Nagano, Z Wu, Y Takahashi - Parasitology research, 2009 - Springer
Research of Trichinella proteins has been conducted with emphasis on excretory–secretory
(E–S) products of muscle larvae because of two reasons. The first is that it has prominent …

What can parasites tell us about the pathogenesis and treatment of asthma and allergic diseases

S Bohnacker, F Troisi, M de los Reyes Jiménez… - Frontiers in …, 2020 - frontiersin.org
The same mechanisms that enable host defense against helminths also drive allergic
inflammation. This suggests that pathomechanisms of allergic diseases represent …

Modulation of specific and allergy‐related immune responses by helminths

E Daniłowicz-Luebert, NL O′ Regan… - BioMed Research …, 2011 - Wiley Online Library
Helminths are master regulators of host immune responses utilising complex mechanisms to
dampen host protective Th2‐type responses and favour long‐term persistence. Such …