Chalcone derivatives: promising starting points for drug design

MN Gomes, EN Muratov, M Pereira, JC Peixoto… - Molecules, 2017 - mdpi.com
Medicinal chemists continue to be fascinated by chalcone derivatives because of their
simple chemistry, ease of hydrogen atom manipulation, straightforward synthesis, and a …

Current developments of coumarin compounds in medicinal chemistry

XM Peng, G LV Damu, C He Zhou - Current pharmaceutical …, 2013 - benthamdirect.com
Coumarin compounds represent an important type of naturally occurring and synthetic
oxygen-containing heterocycles with typical benzopyrone framework. This type of special …

Coumarin hybrids as novel therapeutic agents

S Sandhu, Y Bansal, O Silakari, G Bansal - Bioorganic & medicinal …, 2014 - Elsevier
Naturally occurring coumarins, having wide spectrum of activities such as antioxidant, anti-
inflammatory, anticancer, MAO-B inhibitory and antimicrobial, are frequently used by the …

Copper nanoparticles as inexpensive and efficient catalyst: A valuable contribution in organic synthesis

NK Ojha, GV Zyryanov, A Majee, VN Charushin… - Coordination Chemistry …, 2017 - Elsevier
Copper nanoparticles have been explored as a new class of heterogeneous catalyst in
various chemical transformations. This review surveys the most useful organic …

Pharmacological and nutritional effects of natural coumarins and their structure–activity relationships

JJ Zhu, JG Jiang - Molecular nutrition & food research, 2018 - Wiley Online Library
Coumarins are fused benzene and pyrone ring systems with a wide spectrum of
bioactivities, including antitumor, anti‐inflammation, antiviral, and antibacterial effects. In this …

Combination of changeable π-conjugation and hydrophilic groups for developing water-soluble small-molecule NIR-II fluorogenic probes

X Zhang, S Shen, D Liu, X Li, W Shi, H Ma - Chemical Science, 2023 - pubs.rsc.org
Small-molecule probes emitting in the second near-infrared window (NIR-II) are attracting
great attention because of their deep-tissue imaging ability. However, developing NIR-II …

Coumarins as cholinesterase inhibitors: A review

LG de Souza, MN Rennó, JD Figueroa-Villar - Chemico-biological …, 2016 - Elsevier
The first report in literature of the isolation of coumarin was in the year 1820. After this report,
other papers were published demonstrating the isolation and synthesis of coumarin and …

Natural product coumarins: biological and pharmacological perspectives

MI Hussain, QA Syed, MNK Khattak, B Hafez… - Biologia, 2019 - Springer
Plants produce and release a vast variety of secondary metabolites with diversified
functions, and possess ecological, toxicological and biological effects that mimic the …

Significance of chalcone scaffolds in medicinal chemistry

R Mazumder, Ichudaule, A Ghosh, S Deb… - Topics in Current …, 2024 - Springer
Chalcone is a simple naturally occurring α, β-unsaturated ketone with biological importance,
which can also be easily synthesized in laboratories by reaction between two aromatic …

Antihyperlipidemic activity of high sulfate content derivative of polysaccharide extracted from Ulva pertusa (Chlorophyta)

H Qi, L Huang, X Liu, D Liu, Q Zhang, S Liu - Carbohydrate Polymers, 2012 - Elsevier
In this study, high sulfate content ulvan (HU) was prepared with sulfur trioxide/N, N-
dimethylformamide (SO3–DMF) in formamide, and the antihyperlipidemic activity of ulvan …