Modulation of intracellular copper levels as the mechanism of action of anticancer copper complexes: Clinical relevance

MV Babak, D Ahn - Biomedicines, 2021 - mdpi.com
Copper (Cu) is a vital element required for cellular growth and development; however, even
slight changes in its homeostasis might lead to severe toxicity and deleterious medical …

Promising heterometallic compounds as anticancer agents: Recent studies in vivo

JE López-Hernández, M Contel - Current opinion in chemical biology, 2023 - Elsevier
Over the past decade, interest on multitarget anticancer drugs-including heterometallic
compounds-has increased considerably. Heterometallic species display improved efficacy …

Multinuclear biologically active Ru, Rh, Os and Ir arene complexes

P Štarha - Coordination Chemistry Reviews, 2021 - Elsevier
The development of multinuclear homometallic biologically active complexes is attractive for
modern bioinorganic chemistry, because this concept offers a multiplication of the …

Elucidation of Structure–Activity Relationships in Indolobenzazepine-Derived Ligands and Their Copper (II) Complexes: the Role of Key Structural Components and …

I Kuznetcova, F Bacher, SM Alfadul… - Inorganic …, 2022 - ACS Publications
Indolo [3, 2-d][1] benzazepines (paullones), indolo [3, 2-d][2] benzazepines, and indolo [2, 3-
d][2] benzazepines (latonduines) are isomeric scaffolds of current medicinal interest. Herein …

Inhibition of microtubule dynamics in cancer cells by indole-modified latonduine derivatives and their metal complexes

C Wittmann, AS Sivchenko, F Bacher… - Inorganic …, 2022 - ACS Publications
Indolo [2, 3-d] benzazepines (indololatonduines) are rarely discussed in the literature. In this
project, we prepared a series of novel indololatonduine derivatives and their RuII and OsII …

Synthesis, structural characterization, and bonding analysis of two-coordinate copper (i) and silver (i) complexes of pyrrole-based bis (phosphinimine): new metal …

VK Jha, S Das, V Subramaniyan, T Guchhait… - Dalton …, 2021 - pubs.rsc.org
The reaction between 2, 5-bis (diphenylphosphinomethyl) pyrrole and Me3SiN3 gave the
new pyrrole-based bis (phosphinimine) L1H in an excellent yield. L1H reacts with [CuCl …

Copper (I) complexes of acylthiourea ligands: structural insights and cytotoxic potential

PA Doss, M Dharmasivam… - Applied …, 2024 - Wiley Online Library
The reaction of substituted acylthiourea derivatives (L1–L4) with [(PPh3) 2Cu (μ‐Cl) 2Cu
(PPh3)] in a proper stoichiometric proportion gave the complexes (1–4) in good yields. The …

Triapine derivatives act as copper delivery vehicles to induce deadly metal overload in cancer cells

K Ohui, I Stepanenko, I Besleaga, MV Babak, R Stafi… - Biomolecules, 2020 - mdpi.com
Thiosemicarbazones continue to attract the interest of researchers as potential anticancer
drugs. For example, 3-aminopyridine-2-carboxaldehyde thiosemicarbazone, or triapine, is …

Evaluation of Anticancer Activity of Schiff bases Derived from Pyridine and their Metal Complexes-A Review

R Induleka, CP Anushyaveera… - Oriental Journal Of …, 2022 - search.proquest.com
Cancer is a deadly disease; many treatment strategies are available to cure/treat cancer.
After the metal-based anticancer drug (Cisplatin), metal complexes play a vital role in …

Spectroelectrochemistry

AC González-Baro, G Espino, A Colina… - Springer Handbook of …, 2022 - Springer
This chapter provides a brief review of the main spectroelectrochemical techniques most
frequently used in inorganic chemistry to study and characterize inorganic soluble species …