[HTML][HTML] Plant-derived terpenoids: A plethora of bioactive compounds with several health functions and industrial applications—A comprehensive overview

JS Câmara, R Perestrelo, R Ferreira, CV Berenguer… - Molecules, 2024 - mdpi.com
Terpenoids are a large class of natural secondary plant metabolites which are highly diverse
in structure, formed from isoprene units (C-5), associated with a wide range of biological …

Thymoquinone, as a novel therapeutic candidate of cancers

B Almajali, HAN Al-Jamal, WRW Taib, I Ismail… - Pharmaceuticals, 2021 - mdpi.com
To date, natural products are widely used as pharmaceutical agents for many human
diseases and cancers. One of the most popular natural products that have been studied for …

Treatment of metastatic uveal melanoma: systematic review

C Rodriguez-Vidal, D Fernandez-Diaz… - Cancers, 2020 - mdpi.com
Simple Summary Contrary to other cancers, treatment of human uveal malignant melanoma
metastases has not evolved sufficiently remaining as a great challenge in the field of ocular …

Antitumor effect of Melaleuca alternifolia essential oil and its main component terpinen-4-ol in combination with target therapy in melanoma models

M Di Martile, S Garzoli, M Sabatino, E Valentini… - Cell death …, 2021 - nature.com
Essential oils (EOs) have been recently emerging for their promising biological activities in
preventing tumorigenesis or progression of different tumor histotypes, including melanoma …

Formulation, cellular uptake and cytotoxicity of thymoquinone-loaded PLGA nanoparticles in malignant melanoma cancer cells

WN Ibrahim, L Muizzuddin Bin Mohd Rosli… - International journal …, 2020 - Taylor & Francis
Introduction Thymoquinone (TQ) is the main active compound extracted from Nigella sativa
a traditional herb with wide therapeutic applications and recognizable anticancer properties …

Cutaneous melanoma—a long road from experimental models to clinical outcome: a review

D Coricovac, C Dehelean, EA Moaca, I Pinzaru… - International journal of …, 2018 - mdpi.com
Cutaneous melanoma is a complex disorder characterized by an elevated degree of
heterogeneity, features that place it among the most aggressive types of cancer. Although …

Thymoquinone induces oxidative stress-mediated apoptosis through downregulation of Jak2/STAT3 signaling pathway in human melanoma cells

PK Raut, HS Lee, SH Joo, KS Chun - Food and Chemical Toxicology, 2021 - Elsevier
Melanoma is a highly aggressive and treatment-resistant cancer, and the incidence and
mortality rates are increasing worldwide. Thymoquinone (TQ) is the active component of …

Thymoquinone induces apoptosis of human renal carcinoma Caki-1 cells by inhibiting JAK2/STAT3 through pro-oxidant effect

IG Chae, NY Song, DH Kim, MY Lee, JM Park… - Food and Chemical …, 2020 - Elsevier
Currently, there are limited effective treatment options for renal cell carcinoma (RCC), due to
its poor responses to conventional therapies. Instead of using extrinsic anti-cancer drugs …

Thymoquinone, an active compound of Nigella sativa: role in prevention and treatment of cancer

SA Almatroodi, A Almatroudi, MA Alsahli… - Current …, 2020 - ingentaconnect.com
Background: Cancer is the leading cause of death worldwide and the current mode of
cancer treatment causes side effects on normal cells and are still the key challenges in its' …

Plant-derived terpenoids: a promising tool in the fight against melanoma

P Kłos, D Chlubek - Cancers, 2022 - mdpi.com
Simple Summary Despite the numerous therapies, melanoma remains the deadliest of all
skin cancers; however, plant-derived terpenoids are defense molecules that have proven …