Cisplatin: The first metal based anticancer drug

S Ghosh - Bioorganic chemistry, 2019 - Elsevier
Abstract Cisplatin or (SP-4-2)-diamminedichloridoplatinum (II) is one of the most potential
and widely used drugs for the treatment of various solid cancers such as testicular, ovarian …

Stimuli-responsive therapeutic metallodrugs

X Wang, X Wang, S Jin, N Muhammad, Z Guo - Chemical reviews, 2018 - ACS Publications
The success of platinum-based anticancer agents has motivated the exploration of novel
metal-based drugs for several decades, whereas problems such as drug-resistance and …

The next generation of platinum drugs: targeted Pt (II) agents, nanoparticle delivery, and Pt (IV) prodrugs

TC Johnstone, K Suntharalingam, SJ Lippard - Chemical reviews, 2016 - ACS Publications
The platinum drugs, cisplatin, carboplatin, and oxaliplatin, prevail in the treatment of cancer,
but new platinum agents have been very slow to enter the clinic. Recently, however, there …

Synthetic methods for the preparation of platinum anticancer complexes

JJ Wilson, SJ Lippard - Chemical reviews, 2014 - ACS Publications
The demonstration in the 1960s that cis-diamminedichloroplatinum (II), or cisplatin, inhibits
cellular division of Escherichia coli 1 led to the subsequent discovery that this simple …

Targeting and delivery of platinum-based anticancer drugs

X Wang, Z Guo - Chemical Society Reviews, 2013 - pubs.rsc.org
Platinum-based anticancer drugs occupy a crucial role in the treatment of various malignant
tumours. However, the efficacy and applicability of platinum drugs are heavily restricted by …

Redox activation of metal-based prodrugs as a strategy for drug delivery

N Graf, SJ Lippard - Advanced drug delivery reviews, 2012 - Elsevier
This review provides an overview of metal-based anticancer drugs and drug candidates. In
particular, we focus on metal complexes that can be activated in the reducing environment of …

Recent progress in polymer-based platinum drug delivery systems

H Xiao, L Yan, EM Dempsey, W Song, R Qi, W Li… - Progress in Polymer …, 2018 - Elsevier
Platinum drugs comprise of almost 50% of all currently used anticancer drugs. They are now
widely used in the clinical therapy of various solid tumors, including ovarian, head and neck …

Therapeutic platforms based on gold nanoparticles and their covalent conjugates with drug molecules

L Vigderman, ER Zubarev - Advanced drug delivery reviews, 2013 - Elsevier
This review will first look at the various covalent strategies that have been developed to
attach drugs to gold nanoparticles as well as the strengths and limitations of such strategies …

Functionalization of platinum complexes for biomedical applications

X Wang, X Wang, Z Guo - Accounts of chemical research, 2015 - ACS Publications
Conspectus Platinum-based anticancer drugs are the mainstay of chemotherapy regimens
in clinic. Nevertheless, the efficacy of platinum drugs is badly affected by serious systemic …

Surface chemistry of gold nanorods

ND Burrows, W Lin, JG Hinman, JM Dennison… - Langmuir, 2016 - ACS Publications
Gold nanorods have garnered a great deal of scientific interest because of their unique
optical properties, and they have the potential to greatly impact many areas of science and …